Heparin mimetic peptide nanofiber gel promotes regeneration of full thickness burn injury

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buir.contributor.authorGüler, Mustafa O.
dc.citation.epage127en_US
dc.citation.spage117en_US
dc.citation.volumeNumber134en_US
dc.contributor.authorYergoz, F.en_US
dc.contributor.authorHastar, N.en_US
dc.contributor.authorCimenci, C. E.en_US
dc.contributor.authorOzkan, A. D.en_US
dc.contributor.authorGüler, Mustafa O.en_US
dc.contributor.authorTekinay, A. B.en_US
dc.contributor.authorTekinay, T.en_US
dc.contributor.authorGüler, Mustafa O.en_US
dc.date.accessioned2018-04-12T11:13:19Z
dc.date.available2018-04-12T11:13:19Z
dc.date.issued2017en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractBurn injuries are one of the most common types of trauma worldwide, and their unique physiology requires the development of specialized therapeutic materials for their treatment. Here, we report the use of synthetic, functional and biodegradable peptide nanofiber gels for the improved healing of burn wounds to alleviate the progressive loss of tissue function at the post-burn wound site. These bioactive nanofiber gels form scaffolds that recapitulate the structure and function of the native extracellular matrix through signaling peptide epitopes, which can trigger angiogenesis through their affinity to basic growth factors. In this study, the angiogenesis-promoting properties of the bioactive scaffolds were utilized for the treatment of a thermal burn model. Following the excision of necrotic tissue, bioactive gels and control solutions were applied topically onto the wound area. The wound healing process was evaluated at 7, 14 and 21 days following injury through histological observations, immunostaining and marker RNA/protein analysis. Bioactive peptide nanofiber-treated burn wounds formed well-organized and collagen-rich granulation tissue layers, produced a greater density of newly formed blood vessels, and exhibited increased re-epithelialization and skin appendage development with minimal crust formation, while non-bioactive peptide nanofibers and the commercial wound dressing 3M™ Tegaderm™ did not exhibit significant efficiency over sucrose controls. Overall, the heparin-mimetic peptide nanofiber gels increased the rate of repair of burn injuries and can be used as an effective means of facilitating wound healing.en_US
dc.description.provenanceMade available in DSpace on 2018-04-12T11:13:19Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2017en
dc.embargo.release2019-07-01en_US
dc.identifier.doi10.1016/j.biomaterials.2017.04.040en_US
dc.identifier.issn0142-9612
dc.identifier.urihttp://hdl.handle.net/11693/37432
dc.language.isoEnglishen_US
dc.publisherElsevier Ltden_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.biomaterials.2017.04.040en_US
dc.source.titleBiomaterialsen_US
dc.subjectBurn injuryen_US
dc.subjectHeparinen_US
dc.subjectHydrogelen_US
dc.subjectPeptide nanofiberen_US
dc.subjectSelf-assemblyen_US
dc.subjectBlood vesselsen_US
dc.subjectGelsen_US
dc.subjectHigh temperature effectsen_US
dc.subjectHydrogelsen_US
dc.subjectNanofibersen_US
dc.subjectPeptidesen_US
dc.subjectPolysaccharidesen_US
dc.subjectSelf assemblyen_US
dc.subjectTissueen_US
dc.subjectTissue regenerationen_US
dc.subjectBioactive nanofibersen_US
dc.subjectBurn injuryen_US
dc.subjectHeparinen_US
dc.subjectHistological observationsen_US
dc.subjectNative extracellular matrixen_US
dc.subjectRe-epithelializationen_US
dc.subjectTherapeutic materialsen_US
dc.subjectWound healing processen_US
dc.subjectBiomimeticsen_US
dc.subjectCollagenen_US
dc.subjectHeparinen_US
dc.subjectNanofiberen_US
dc.subjectRNAen_US
dc.subjectHeparinen_US
dc.subjectNanofiberen_US
dc.subjectPeptideen_US
dc.subjectAngiogenesisen_US
dc.subjectAnimal experimenten_US
dc.subjectAnimal modelen_US
dc.subjectAnimal tissueen_US
dc.subjectArticleen_US
dc.subjectBurnen_US
dc.subjectControlled studyen_US
dc.subjectDebridementen_US
dc.subjectDensityen_US
dc.subjectEpithelizationen_US
dc.subjectFull thickness skin graften_US
dc.subjectGelen_US
dc.subjectImmunohistochemistryen_US
dc.subjectIn vivo studyen_US
dc.subjectMaleen_US
dc.subjectMouseen_US
dc.subjectNonhumanen_US
dc.subjectPriority journalen_US
dc.subjectRNA analysisen_US
dc.subjectSkin appendageen_US
dc.subjectTissue regenerationen_US
dc.subjectWound dressingen_US
dc.subjectWound healingen_US
dc.subjectAnimalen_US
dc.subjectBagg albino mouseen_US
dc.subjectBurnen_US
dc.subjectChemistryen_US
dc.subjectCircular dichroismen_US
dc.subjectGelen_US
dc.subjectPhysiologyen_US
dc.subjectScanning electron microscopyen_US
dc.subjectTissue scaffolden_US
dc.subjectAnimalsen_US
dc.subjectBurnsen_US
dc.subjectCircular dichroismen_US
dc.subjectGelsen_US
dc.subjectHeparinen_US
dc.subjectImmunohistochemistryen_US
dc.subjectMaleen_US
dc.subjectMiceen_US
dc.subjectMice, inbred BALB Cen_US
dc.subjectMicroscopy, electron, scanningen_US
dc.subjectNanofibersen_US
dc.subjectPeptidesen_US
dc.subjectTissue scaffoldsen_US
dc.subjectWound healingen_US
dc.titleHeparin mimetic peptide nanofiber gel promotes regeneration of full thickness burn injuryen_US
dc.typeArticleen_US

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