Scholarly Publications - UNAM
Permanent URI for this collectionhttps://hdl.handle.net/11693/117076
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Item Open Access Evaluation of the follicular fluid thiol/disulfide balance among patients with poor ovarian response(Korean Society for Reproductive Medicine, 2025-06) Türkyılmaz, Esengul; Erbaba, Begün; Neşelioğlu, Salim; Yılmaz, Nafiye Karakaş; Tekin, Özlem MoraloğluObjective
This study aimed to compare the thiol/disulfide balance, myeloperoxidase, and ischemia-modified albumin levels in the follicular fluid (FF) of poor ovarian response (POR) and normal ovarian response (NOR) women who received intracytoplasmic sperm injection (ICSI).Methods
The study was performed between March 2021 and April 2022 at the Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Ankara City Hospital. The study included 27 POR and 35 NOR women who underwent ICSI. FF was obtained after the controlled ovarian stimulation cycle. The FF thiol/disulfide balance was detected using spectrophotometric methods. A correlation analysis was conducted to determine whether these oxidative stress markers could contribute to predicting oocyte quality.Results
Disulfide levels were significantly higher in the NOR group than in the POR group (p=0.014). The number of fertilized egg (2PN) oocytes was positively correlated with the total thiol level (r=0.258, p=0.046). The disulfide level was positively correlated with the anti-Müllerian hormone level (r=0.262, p=0.039) and the total number of retrieved oocytes (r=0.335, p=0.008).Conclusion
The disulfide levels differed significantly between the NOR and POR groups. The statistically significant differences of fewer metaphase II oocytes and lower percentage of good-quality embryos in the NOR group compared to the POR group might have resulted from the NOR group’s elevated disulfide levels. The total thiol levels correlated with the total of 2PN oocytes. Future studies should examine the thiol/disulfide balance at assisted reproductive technology centers to predict which oocytes could be fertilized.Item Embargo Cu doping of Sb₂Se₃ thin films via thermal evaporation: tailoring structural and optical properties for enhanced photovoltaic performance(Elsevier B.V., 2025-07-29) Işık, M.; Surucu O.; Bektaş, Tunç; Parlak M.In this study, Cu-doped Sb₂Se₃ thin films were successfully grown using the thermal evaporation method, and their structural and optical properties were systematically investigated. Three different samples with thickness of ∼400 nm were analyzed: undoped, 1 %, and 2 % Cu-doped Sb₂Se₃. X-ray diffraction (XRD) analysis revealed well-defined peaks, confirming the orthorhombic crystalline nature of the films. Scanning electron microscopy (SEM) images showed a uniform surface morphology without any significant defects. The optical properties were examined through transmission measurements. The band gap energy determined by Tauc analysis decreased from 1.27 to 1.21 eV as the Cu doping increased from 0 % to 2 %, indicating that Cu incorporation modifies the electronic structure of Sb₂Se₃. Similarly, Urbach energy increased from 0.148 to 0.168 eV depending on Cu content, suggesting a rise in localized states due to increased structural disorder. These findings demonstrate that Cu doping influences the electronic structure and defect states of Sb₂Se₃, which is crucial for optimizing its performance in photovoltaic and optoelectronic applications.Item Open Access Cooperative catalytic role of Co and Mn sites on LaCoₓMn₁₋ₓO₃ perovskite nanoparticles in CO and NO oxidation(American Chemical Society, 2025-08-18) Ercan, Kerem Emre; Karatok, Mustafa; Say, Zafer; Kurt, Merve; Sika-Nartey, Abel Tetteh; Özensoy, EmrahPerovskites have significant potential to improve efficiency, reduce the costs of conventional oxidation catalysts, and contribute to cleaner and more sustainable energy solutions. However, numerous structural factors influencing their catalytic performance are still a subject to debate. In this study, simple perovskite nanoparticles in the form of $LaCoO_3$ (LC) and $LaMnO_3$ (LM), as well as $LaCo_{x}Mn_{1–x}O_3$ (LCM)-mixed B-site perovskites with different B-site cations, were synthesized and their performances in $CO$ oxidation and $NO$ oxidation reactions were examined. The $LaCo_{0.8}Mn_{0.2}O_3$ catalyst exhibited the highest catalytic activity in both $CO$ and $NO$ oxidation reactions, surpassing the 1 wt $%Pt/γ-Al_2O_3$ benchmark nanoparticle catalyst and other currently investigated perovskite nanoparticles. Co sites (predominantly $Co^{3+}$) in the optimized $LaCo_{0.8}Mn_{0.2}O_3$ catalyst were found to be enriched in electron density, while Mn sites (mostly in $Mn^{4+}$ form) were found to be more electron deficient as opposed to LC and LM. $LaCo_{0.8}Mn_{0.2}O_3$ not only released significantly greater amounts of oxygen and generated larger extents of oxygen vacancies than LC and LM under reducing conditions but also achieved this at favorably lower temperatures. In light of the current results, we report that Co sites in LCM operate as the main active site during both $CO$ and $NO$ oxidation by enabling stabilization and activation of $O_2$ (ads), while Mn sites mainly serve as promoters by increasing the adsorption strength of $CO$ (ads) and $NO$ (ads) as well as facilitating oxygen vacancy formation and vacancy regeneration, where oxygen vacancies were also found to contribute particularly to the $NO$ oxidation reaction within the currently investigated thermal window. These findings demonstrate that the electronic properties of LCM can be systematically tailored at the nanometer scale in a versatile manner to address different reactivity requirements of challenging catalytic reactions.Item Embargo Graphene oxide-cellulose composite cryogels for extracellular vesicle isolation(Elsevier Inc., 2025-11-02) Saylan, Yeşeren; Altıntaş, Özge; Yılmaz, Eylul Gülşen; Akceoğlu, Garbis Atam; İnci, Fatih; Yılmaz, Fatma; Denizli, AdilHerein, we present an innovative approach for the selective and high-efficiency isolation of extracellular vesicles (EVs) derived from microfluidic chips that replicate the tumor microenvironment. This is achieved through the development of graphene oxide-cellulose-based composite cryogels imprinted with EVs. In the experiments, MCF-7 cells were cultured under flow conditions within microfluidic chips, simulating the dynamic tumor microenvironment. The isolated EVs were comprehensively characterized in terms of biological, morphological, and quantitative attributes using scanning electron microscopy and nanoparticle tracking analysis. Subsequently, the EVs were imprinted onto graphene oxide-cellulose-based composite cryogels, yielding a novel polymeric material designed for highly selective EV isolation. The physicochemical properties of the composite cryogels were thoroughly analyzed using multiple characterization techniques, and their kinetic performance was evaluated under varying parameters (pH, concentration, temperature, ionic strength, flow rate and selectivity). The maximum adsorption capacity was calculated to be 231 particles/g in a pH 5.0 buffer solution at room temperature. Non-composite and non-imprinted composite cryogels were also prepared for comparison experiments. Finally, the efficacy and validation of the platform were confirmed via high-performance liquid chromatography (HPLC) analysis, demonstrating its potential as a powerful tool for EV isolation in cancer research.Item Embargo Computational studies for the development of extracellular vesicle-based biosensors(Elsevier BV, 2025-06-01) Atabay, Maryam; İnci, Fatih; Saylan, YeşerenCancer affects millions of people, and early detection and efficient treatment are two strong levers to hurdle this disease. Recent studies on exosomes, a subset of extracellular vesicles, have deliberately shown the potential to function as a biomarker or treatment tool, thereby attracting the attention of researchers who work on developing biosensors. Due to the ability of computational methods to predict of the behavior of biomolecules, the combination of experimental and computational methods would enhance the analytical performance of the biosensor, including sensitivity, accuracy, and specificity, even detecting such vesicles from bodily fluids. In this regard, the role of computational methods such as molecular docking, molecular dynamics simulation, and density functional theory is overviewed in the development of biosensors. This review highlights the investigations and studies that have been reported using these methods to design exosome-based biosensors. This review concludes with the role of the quantum mechanics/molecular mechanics method in the investigation of chemical processes of biomolecular systems and the deficiencies in using this approach to develop exosome-based biosensors. In addition, the artificial intelligence theory is explained briefly to show its importance in the study of these biosensors.Item Open Access High-power laser-induced synthesis of Ni-based metal-organic framework for electrocatalytic, and glucose-sensing applications(Institute of Electrical and Electronics Engineers Inc., 2025-08-15) Mutlu, Saliha; Ortaç, Bülend; Karatutlu, Ali; Gorkan, Taylan; Durgun, Engin; Söyler, Dilek; Söylemez, Saniye; Yılmaz, Sevil Savaşkan; Arsu, NergisPure nickel-based metal-organic frameworks (Ni-MOFs) are prepared primarily using mechanochemical synthesis, hydrothermal, and solvothermal procedures. Upon synthesizing MOFs using these traditional methods, the additional laser processing step was applied to MOF derivatives for the features of engineering structural defects and their applications in the fields of catalysis, environmental protection, and energy.Item Open Access Recent advances in GaN-based semiconductor lasers(Institute of Physics Publishing Ltd., 2025-07-17) Zhao, Chunyu; Tan, Swee Tiam; Demir, Hilmi VolkanIII-nitride semiconductor lasers have made remarkable progress in recent years, particularly thanks to their ability to be tuned from the ultraviolet to the infrared. This comprehensive review explores the latest developments in GaN-based semiconductor lasers, with a specific focus on edge-emitting laser, vertical-cavity surface-emitting laser, photonic crystal or nanocrystal surface-emitting laser, and whispering gallery mode laser diodes. The review delves into each laser type’s distinctive properties and potential applications, evaluating their performance while identifying current challenges. Finally, this review aims to shed light on challenges and prospects in GaN-based laser development.Item Open Access Alignment teaching assisted fully automated mechanical dicing of MEMS and NEMS devices(Institute of Physics Publishing Ltd., 2025-04-22) Rashid Mahmood, Muhammad; Griesmann, Jens; Chervenkov, Sotir; Yılmaz, MehmetIn the dynamic landscape of semiconductor manufacturing, the demand for innovative and efficient techniques is ever-growing. Dicing is a singulation process where a machine known as a dicing saw or dicer uses a diamond blade or laser to separate dies from a wafer through a manual, semi-automated, or fully automated process. In diamond blade or mechanical dicing, the dicing saw utilizes a thin blade to cut through a wafer. This paper presents the design and implementation of an alignment teaching-assisted fully automated dicing process for the singulation of microelectromechanical systems (MEMS) devices. A pseudo-MEMS device with potential alignment targets was designed and manufactured by conventional microfabrication techniques. Alignment teaching operation was optimized for the dicing saw by finding the most appropriate alignment targets, as alignment teaching is as a pre-requisite for realizing both auto-alignment and automated dicing processes. A systematic trial-and-error approach was employed to discover the most suitable alignment targets from a pool of twenty-three potential target patterns. A circle was identified as an excellent macro target, while the addition symbol, hash symbol, and rectangle-pair were determined to be the most appropriate micro targets. The developed versatile singulation process is capable of executing an alignment teaching assisted fully automated (i.e. a total of one-click to initiate and finalize) dicing for singulating MEMS device chips, irrespective of alignment target color, die size, or wafer material. Furthermore, we developed, and experimentally validated, a mathematical model to estimate the total process time for the automated dicing.Item Open Access Wavelength filtering in negative curvature hollow-core fibers(EDP Sciences, 2025-09-22) Siddiqui, Muhammad Zain; Akosman, Ahmet Emin; Ordu, MustafaA negative curvature hollow-core fiber design with double pole-anchored cladding elements is numerically proposed for spectral filtering. The fiber structure is investigated for improvement in filtering ability through manipulation of the pole length. The findings reveal reduced confinement losses as low as 0.0003 dB/km for filtered and 0.0054 dB/km for unfiltered wavelengths yielding enhanced loss modulation depth.Item Embargo Energy absorber inspired by spider webs(Elsevier Ltd, 2025-08-15) Yavuz, Koray; Jahangirova, Seymur; Görgülüarslan, Recep M.The spider orb web has evolved to efficiently absorb the energy of flying insects colliding with it. In this study, a novel three-dimensional lattice structure inspired by the specific structural characteristics of the spider orb web was designed and optimized to create a new lattice design. The design was optimized for energy absorption and energy absorption efficiency using a size optimization procedure with numerical modeling based on beam elements under quasi-static compression loading. This optimized lattice was additively manufactured and subjected to quasi-static compression testing. Numerical results for energy absorption and compression behavior showed good agreement with experimental findings. Additionally, numerical analysis of the optimized lattice was performed using solid elements to predict the energy absorption behavior more accurately, and the results showed even better agreement with experimental data. The resulting lattice also demonstrated improved energy absorption performance compared to existing lattice structures.Item Embargo Electrolyte-free potassium ions intercalated in 2D layered metal oxide for imitating spatiotemporal biological neural dynamics(Elsevier Ltd, 2025-06) Noh, Gichang; Kim, Jeongho; Woo, Dong Yeon; Kim, Min-gyu; Yoo, Hyeri; Jeong, Han Beom; Jo, Yooyeon; Park, Eunpyo; Lee, Dae Kyu; Kim, Min Jee; Jo, Min-kyung; Kim, In Soo; Kasırga, Talip Serkan; Ha, Dong Han; Kim, Soo Young; Hwang, Gyu Weon; Kim, Sangtae; Lee, Chul-Ho; Yang, Heejun; Jeong, Hu Young; Kang, Kibum; Kwak, Joon YoungAlkali ions are crucial to physiological neural activities and their dynamics can be implemented in various iontronics. For the host materials for alkali ions, 2D layered materials have become the preferred choice thanks to their facilitating ion accommodation and movement between layers. Nevertheless, challenges such as the need for external electrolytes, pre-fabrication for ion intercalation, and thermodynamic stability during ion movements still persist. Consequently, the comprehensive understanding of the electrical dynamics associated with alkali ion movement has rarely been demonstrated in 2D layered materials so far. Here, we engineered an electrolyte-free high-crystalline 2D layered MnO₂ nanoplate with potassium ions by metal–organic chemical vapor deposition. The combination of potassium ions and layered MnO₂ exhibits electrically induced ion migration coupled with a subsequent phase transition, resulting in negative differential resistance. Furthermore, the material's distinct hybrid plasticity, driven by its ion dynamics, provides a sophisticated platform for sequential motion recognition, valuable for assessing continuous motion across varied subjects. Finally, we demonstrate the broad applicability of our 2D K-MnO₂ and highlight its versatility in spatiotemporal ion modulation within three-terminal structures, showing potential for future advancements.Item Embargo Electro-optical evaluation of Cu¹⁺ and Cu²⁺ states in copper-doped CdSe colloidal quantum wells(American Chemical Society, 2026-01-29) Yu, Junhong; Wang, Ke; Han, Yadong; Lian, Zhenzhong; Hou, Songyan; Cao, Chang; Demir, Hilmi Volkan; Jasieniak, Jacek J.; Sharma, ManojResolving the ambiguous oxidation state of copper dopants responsible for the large Stokes-shifted emission in CdSe colloidal quantum wells (CQWs) is critical for harnessing their emerging optoelectronic properties. Employing carrier injection to tune the population distribution between Cu¹⁺/Cu²⁺ centers and in situ monitoring of the copper-related emission (CE), we have revealed that the CE band undergoes blueshifting, intensity quenching, and line width broadening with gradually increased Cu²⁺ states. Time-resolved CE dynamics and intragap absorption further confirm that Cu²⁺ states generate narrow, inefficient emission with minimal Stokes shifts due to trap-mediated Auger recombination, reduced radiative center energy spanning, and Fermi-level shifts. Accordingly, we identify Cu¹⁺ as the dominant species that produces the bright, broad CE band with its hallmark large Stokes shift. This work not only presents mechanistic clarifications but also provides an effective approach to electrically modulate defect emissions in CQWs.Item Open Access Correction to “multifaceted effects of the dielectric component within plasmon-assisted light-emitting structures”(American Chemical Society, 2025-12-17) Kulakovich, Olga; Muravitskaya, Alina; Ramanenka, Andrei; Efimova, Taisia; Krukov, Vitali; Mutlugun, Evren; Kulak, Anatoly; Demir, Hilmi Volkan; Wang, Zhiming; Gaponenko, SergeyIn the original version of the article, the affiliation of Hilmi Volkan Demir needs following correction. The first affiliation of the author “Department of Electrical-Electronics Engineering, Abdullah Gul University, Kayseri 38080, Turkey” should be replaced by the affiliation “UNAM – Institute of Materials Science and Nanotechnology and The National Nanotechnology Research Center and Department of Electrical and Electronics Engineering, Department of Physics, Bilkent University, Ankara 06800, Turkey”. Therefore, the correct affiliations for H.V.D. are “UNAM – Institute of Materials Science and Nanotechnology and The National Nanotechnology Research Center and Department of Electrical and Electronics Engineering, Department of Physics, Bilkent University, Ankara 06800, Turkey; LUMINOUS! Center of Excellence for Semiconductor Lighting and Displays, School of Electrical and Electronic Engineering, School of Physical and Mathematical Sciences, School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore”.Item Open Access Spectral width of maximum deposition eigenchannels in diffusive media(American Physical Society, 2025-04-11) McIntosh, R. E.; Goetschy, A.; Bender, N.; Yamilov, A.; Hsu, C. W.; Yılmaz, Hasan; Cao, H.The maximum deposition eigenchannel provides the largest possible power delivery to a target region inside a diffusive medium by optimizing the incident wavefront of a monochromatic beam. It originates from constructive interference of scattered waves, which is frequency sensitive. We investigate the spectral width of the maximum deposition eigenchannels over a range of target depths using numerical simulations of a 2D diffusive system. Compared to tight focusing into the system, power deposition to an extended region is more sensitive to frequency detuning. The spectral width of enhanced delivery to a large target displays a rather weak, nonmonotonic variation with target depth, in contrast to a sharp drop of focusing bandwidth with depth. While the maximum enhancement of power deposited within a diffusive system can exceed that of power transmitted through it, this comes at the cost of a narrower spectral width. We investigate the narrower deposition width in terms of the constructive interference of transmission eigenchannels within the target. We further observe that the spatial field distribution inside the target region decorrelates more slowly with spectral detuning than the power decay of the maximum deposition eigenchannel. Additionally, absorption increases the spectral width of deposition eigenchannels, but the depth dependence remains qualitatively identical to that without absorption. These findings hold for any diffusive waves, including electromagnetic waves, acoustic waves, pressure waves, mesoscopic electrons, and cold atoms.Item Embargo Disorder-driven critical behavior of complex susceptibility in an amorphous ferromagnet(Elsevier B.V., 2025-04-24) Özüm, S.; Gülpınar, G.; Sünnetçi, Elif; Erdem, R.The disorder-driven critical, multicritical, and phase coexistence characteristics of the complex magnetic susceptibility for the Blume-Capel model with a uniaxial anisotropy term that fluctuates in magnitude are analyzed within the framework of the linear response theory. The generalized flux conjugate to its generalized force is formulated as the time derivative of the magnetization. The stationary solution of the kinetic equation in a sinusoidal external magnetic field yields the magnetic dispersion and absorption factors χ1(ω), χ2(ω). The thermal behavior of ac susceptibility is examined thoroughly, focusing on the temperature dependencies of magnetic dispersion and absorption factors near first, second-order, and tricritical points. Crystal field variances of χ1(ω) and χ2(ω) are shown in the neighborhood of two successive first-order transitions between ordered and disordered critical points, where phase transitions occur between ordered and partly ordered phases.Item Open Access Acoustic gas sensing with weakly coupled mems resonators(Institute of Electrical and Electronics Engineers Inc., 2025-03-19) Erkan, Derin; Aslan, Ahmet Arif; Tatar, ErdinçMost of the current gas sensors are individually developed and limited with the detectable gas species due to their material or wavelength dependent sensing technology. We propose an acoustic gas sensing method that utilizes the weak coupling between specialized MEMS resonators originating from the cavity resonance, for the first time. The method directly captures the cavity resonance with inherently strong SNR and can detect any gas. We achieve >7X sensitivity compared to the previously proposed damping and frequency based measurements. We demonstrate the coupling with cavity/no cavity experiments and show the successful sensor operation up to 95% CO2 concentration.Item Open Access The origin of gate degradation under HTRB operation: Buffer engineering to suppress impact ionization in GaN HEMT(Institute of Electrical and Electronics Engineers Inc., 2025-12-15) Soydan, Mahmut Can; Joya, Amir Ali; Ghobadi, Amir; Özbay, EkmelThis study investigates the origin of gate degradation in AlGaN/GaN HEMTs under high-temperature reverse bias (HTRB) conditions and proposes a buffer engineering strategy to mitigate this degradation. Transmission electron microscopy (TEM) analysis reveals the presence of a thin oxide layer between the gate and AlGaN contact. It is found that the holes generated through impact ionization (under high electric fields of HTRB operation), are directed toward the gate due to the intense local electric field under the gate and the field plate overhang, and are accumulated under this energetic barrier. Consequently, these trapped holes cause gate degradation and increased gate leakage. To address this issue, impact ionization, as the initial forcing mechanism of the degradation, is suppressed via thinning the channel GaN (C-GaN) layer. This improvement is attributed to the suppression of the local electric field near the gate region in thin C-GaN HEMTs. Additionally, the impact of C-GaN thinning on breakdown characteristics and RF performance is discussed. Overall, the findings provide insights into the root cause of gate degradation and offer a buffer engineering strategy to minimize gate degradation under deep off-state stress. This approach enhances the reliability of future high-power and high-frequency GaN HEMTs, contributing to their long-term performance in demanding applications.Item Open Access Electrospun gelatin nanofibers encapsulating cyclodextrin-eugenol and cyclodextrin-thymol inclusion complexes for nutraceutical delivery(American Chemical Society, 2026-02-01) Çelebioğlu, Aslı; Topuz, Fuat; Aboelkheir, M.; Uyar, TamerBioactive compounds such as eugenol and thymol offer significant health benefits but suffer from poor aqueous solubility and stability. To address these limitations, inclusion complexes (ICs) of eugenol and thymol with hydroxypropyl-βcyclodextrin (HP-β-CD) were prepared and subsequently encapsulated into fast-disintegrating gelatin nanofibers via electrospinning using an acetic acid/water solvent system. For comparative purposes, IC-loaded and CD-free gelatin films were also fabricated to evaluate structural and functional differences. Scanning electron microscopy (SEM) confirmed the production of uniform, bead-free submicron fibers. Structural analyses via Fourier transform infrared (FTIR) and differential scanning calorimetry (DSC) verified successful complexation and homogeneous incorporation, while thermogravimetric analysis (TGA) demonstrated the enhanced thermal stability of the bioactive agents. 1 H NMR analysis determined the complexation stoichiometry as ∼0.5:1 for eugenol and ∼0.7:1 for thymol systems. In terms of functional performance, nanofibrous mats demonstrated superior water solubility compared to films, with IC-loaded nanofibers reaching up to 87.7% solubility versus 56.4% for film formulations. Furthermore, highperformance liquid chromatography (HPLC) analysis revealed that IC-loaded nanofibers offered significantly faster and higher release rates. While films exhibited a slower profile, nanofibers achieved burst release within 10 min, and the inclusion of CDs enhanced the release capacity by 2- to 3-fold compared to pure bioactive-loaded fibers. These quantitative comparisons confirm that electrospun gelatin nanofibers containing HP-β-CD ICs provide a robust platform for the rapid oral delivery of natural bioactives.Item Open Access Upper bounds on focusing light through multimode fibers(American Physical Society, 2025-11-04) Ammar, Amna; Şener, Sarp Feykun; Ercan, Mert; Yılmaz, HasanWavefront shaping enables precise control of light propagation through multimode fibers (MMFs), facilitating diffraction-limited focusing for applications such as high-resolution single-fiber imaging and high-power fiber amplifiers. While the theoretical intensity enhancement at the focal point is dictated by the number of input degrees of freedom, practical constraints - such as phase-only modulation and experimental noise - impose significant limitations. Despite its importance, the upper bounds of enhancement under these constraints remain largely unexplored. In this work, we establish a theoretical framework to predict the fundamental limits of intensity enhancement with phase-only modulation in the presence of noise-induced phase errors, and we experimentally demonstrate wavefront shaping that approaches these limits. Our experimental results confirm an enhancement factor of 5000 in a large-core MMF, approaching the theoretical upper bound, enabled by noise-tolerant wavefront shaping. These findings provide key insights into the limits of phase-only control in MMFs, with profound implications for single-fiber imaging, optical communication, high-power broad-area fiber amplification, and beyond.Item Embargo Lasing from brillouin zone folding guided resonances(American Chemical Society, 2025-09-25) Chua, Matthew R.; Ding, Lu; Liang, Xiao; Dabard, Corentin; Wang, Wudeng; Akhil, Syed; Durmusoglu, Emek Goksu; Tjiptoharsono, Febiana; Demir, Hilmi Volkan; Paniagua-Domínguez, Ramón; Kuznetsov, Arseniy I.High-quality factor (Q-factor) nanophotonic cavities are critical components in applications such as lasing and nonlinear optics. However, to obtain out-of-plane lasing emission and a low lasing threshold, the lasing mode must fulfill the contradictory requirement of coupling to the light cone while maintaining a high Q-factor. One relatively unexplored method to design such modes consists of using a Brillouin Zone folding guided resonance (BZF-GR) as the high Q-factor mode for lasing. In such a design, guided modes are “folded” into the light cone via periodic perturbations, allowing fine control of the Q-factor throughout momentum space. In this paper, we experimentally demonstrate the use of such a BZF-GR to achieve vertical emission lasing from a nanophotonic cavity with colloidal quantum dots as a gain medium. The lowest lasing threshold fluence under nanosecond pump is (20.4 ± 0.3) μJ cm–2. When considering the absorption, this value falls to (4.08 ± 0.08) μJ cm–2. This work presents a method of designing lasing modes that may be further developed for use in low-threshold nanoscale lasers.