Quercetin/β-cyclodextrin inclusion complex embedded nanofibres: slow release and high solubility

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buir.contributor.authorUyar, Tamer
buir.contributor.authorDurgun, Engin
buir.contributor.orcidUyar, Tamer|0000-0002-3989-4481
dc.citation.epage871en_US
dc.citation.spage864en_US
dc.citation.volumeNumber197en_US
dc.contributor.authorAytac Z.en_US
dc.contributor.authorKusku, S. I.en_US
dc.contributor.authorDurgun, Enginen_US
dc.contributor.authorUyar, Tameren_US
dc.date.accessioned2018-04-12T10:55:04Z
dc.date.available2018-04-12T10:55:04Z
dc.date.issued2016-04en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractElectrospinning of polyacrylic acid (PAA) nanofibres (NF) incorporating β-cyclodextrin inclusion complex (β-CD-IC) of quercetin (QU) was performed. Here, β-CD was used as not only the crosslinking agent for PAA nanofibres but also as a host molecule for inclusion of QU. The phase solubility test showed enhanced solubility of QU due to the inclusion complexation; in addition, the stoichiometry of QU/β-CD-IC was determined to be 1:1. Computational modelling studies confirmed that 1:1 and 1:2 complex formation are desirable; 1:1 complex formation was chosen to have higher weight loading of QU. SEM images showed that PAA/QU/β-CD-IC-NF were bead-free and uniform. XRD indicated that PAA/QU/β-CD-IC-NF were amorphous in nature without the crystalline peaks of QU. Comparative results revealed that the release profile of QU from PAA/QU/β-CD-IC-NF was much slower but greater in total than from PAA/QU/β-CD-IC-film. Moreover, high antioxidant activity and photostability of QU was achieved in PAA/QU/β-CD-IC-NF.en_US
dc.description.provenanceMade available in DSpace on 2018-04-12T10:55:04Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2016en
dc.identifier.doi10.1016/j.foodchem.2015.11.051en_US
dc.identifier.issn0308-8146
dc.identifier.urihttp://hdl.handle.net/11693/36837
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttps://doi.org/10.1016/j.foodchem.2015.11.051en_US
dc.source.titleFood Chemistryen_US
dc.subjectAntioxidant activityen_US
dc.subjectElectrospinningen_US
dc.subjectModellingen_US
dc.subjectNanofibresen_US
dc.subjectPhase solubilityen_US
dc.subjectPhotostabilityen_US
dc.subjectPolyacrylic aciden_US
dc.subjectQuercetinen_US
dc.subjectβ-Cyclodextrinen_US
dc.subjectAntioxidantsen_US
dc.subjectComplexationen_US
dc.subjectCyclodextrinsen_US
dc.subjectElectrospinningen_US
dc.subjectFlavonoidsen_US
dc.subjectModelsen_US
dc.subjectOrganic acidsen_US
dc.subjectPhenolsen_US
dc.subjectSolubilityen_US
dc.subjectSpinning (fibers)en_US
dc.subjectAnti-oxidant activitiesen_US
dc.subjectPhase solubilityen_US
dc.subjectPhoto-stabilityen_US
dc.subjectPolyacrylic acidsen_US
dc.subjectQuercetinen_US
dc.subjectNanofibersen_US
dc.subject2,2-diphenyl-1-picrylhydrazylen_US
dc.subjectAntioxidanten_US
dc.subjectBeta cyclodextrinen_US
dc.subjectBeta cyclodextrin derivativeen_US
dc.subjectBiphenyl derivativeen_US
dc.subjectDrug carrieren_US
dc.subjectNanofiberen_US
dc.subjectPicric aciden_US
dc.subjectQuercetinen_US
dc.subjectChemical structureen_US
dc.subjectChemistryen_US
dc.subjectDrug formulationen_US
dc.subjectDrug releaseen_US
dc.subjectDrug stabilityen_US
dc.subjectParticle sizeen_US
dc.subjectScanning electron microscopyen_US
dc.subjectSolubilityen_US
dc.subjectSurface propertyen_US
dc.subjectX ray diffractionen_US
dc.subjectAntioxidantsen_US
dc.subjectBeta-Cyclodextrinsen_US
dc.subjectBiphenyl Compoundsen_US
dc.subjectDrug Carriersen_US
dc.subjectDrug Compoundingen_US
dc.subjectDrug Liberationen_US
dc.subjectDrug Stabilityen_US
dc.subjectMicroscopy, Electron, Scanningen_US
dc.subjectModels, Molecularen_US
dc.subjectNanofibersen_US
dc.subjectParticle Sizeen_US
dc.subjectPicratesen_US
dc.subjectQuercetinen_US
dc.subjectSolubilityen_US
dc.subjectSurface Propertiesen_US
dc.subjectX-Ray Diffractionen_US
dc.titleQuercetin/β-cyclodextrin inclusion complex embedded nanofibres: slow release and high solubilityen_US
dc.typeArticleen_US

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