Quercetin/β-cyclodextrin inclusion complex embedded nanofibres: slow release and high solubility

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Quercetinβ-cyclodextrin inclusion complex embedded nanofibres Slow release and high solubility.pdf (1.43 MB)

Date

2016-04

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Source Title

Food Chemistry

Print ISSN

0308-8146

Electronic ISSN

Publisher

Elsevier

Volume

197

Issue

Pages

864 - 871

Language

English

Type

Article

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Abstract

Electrospinning of polyacrylic acid (PAA) nanofibres (NF) incorporating β-cyclodextrin inclusion complex (β-CD-IC) of quercetin (QU) was performed. Here, β-CD was used as not only the crosslinking agent for PAA nanofibres but also as a host molecule for inclusion of QU. The phase solubility test showed enhanced solubility of QU due to the inclusion complexation; in addition, the stoichiometry of QU/β-CD-IC was determined to be 1:1. Computational modelling studies confirmed that 1:1 and 1:2 complex formation are desirable; 1:1 complex formation was chosen to have higher weight loading of QU. SEM images showed that PAA/QU/β-CD-IC-NF were bead-free and uniform. XRD indicated that PAA/QU/β-CD-IC-NF were amorphous in nature without the crystalline peaks of QU. Comparative results revealed that the release profile of QU from PAA/QU/β-CD-IC-NF was much slower but greater in total than from PAA/QU/β-CD-IC-film. Moreover, high antioxidant activity and photostability of QU was achieved in PAA/QU/β-CD-IC-NF.

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Keywords

Antioxidant activity , Electrospinning , Modelling , Nanofibres , Phase solubility , Photostability , Polyacrylic acid , Quercetin , β-Cyclodextrin , Antioxidants , Complexation , Cyclodextrins , Electrospinning , Flavonoids , Models , Organic acids , Phenols , Solubility , Spinning (fibers) , Anti-oxidant activities , Phase solubility , Photo-stability , Polyacrylic acids , Quercetin , Nanofibers , 2,2-diphenyl-1-picrylhydrazyl , Antioxidant , Beta cyclodextrin , Beta cyclodextrin derivative , Biphenyl derivative , Drug carrier , Nanofiber , Picric acid , Quercetin , Chemical structure , Chemistry , Drug formulation , Drug release , Drug stability , Particle size , Scanning electron microscopy , Solubility , Surface property , X ray diffraction , Antioxidants , Beta-Cyclodextrins , Biphenyl Compounds , Drug Carriers , Drug Compounding , Drug Liberation , Drug Stability , Microscopy, Electron, Scanning , Models, Molecular , Nanofibers , Particle Size , Picrates , Quercetin , Solubility , Surface Properties , X-Ray Diffraction

Citation

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http://hdl.handle.net/11693/36837

item.page.isversionof

https://doi.org/10.1016/j.foodchem.2015.11.051

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Institute of Materials Science and Nanotechnology (UNAM)
Nanotechnology Research Center (NANOTAM)