Quercetin/β-cyclodextrin inclusion complex embedded nanofibres: slow release and high solubility

Date
2016-04
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Source Title
Food Chemistry
Print ISSN
0308-8146
Electronic ISSN
Publisher
Elsevier
Volume
197
Issue
Pages
864 - 871
Language
English
Type
Article
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Abstract

Electrospinning of polyacrylic acid (PAA) nanofibres (NF) incorporating β-cyclodextrin inclusion complex (β-CD-IC) of quercetin (QU) was performed. Here, β-CD was used as not only the crosslinking agent for PAA nanofibres but also as a host molecule for inclusion of QU. The phase solubility test showed enhanced solubility of QU due to the inclusion complexation; in addition, the stoichiometry of QU/β-CD-IC was determined to be 1:1. Computational modelling studies confirmed that 1:1 and 1:2 complex formation are desirable; 1:1 complex formation was chosen to have higher weight loading of QU. SEM images showed that PAA/QU/β-CD-IC-NF were bead-free and uniform. XRD indicated that PAA/QU/β-CD-IC-NF were amorphous in nature without the crystalline peaks of QU. Comparative results revealed that the release profile of QU from PAA/QU/β-CD-IC-NF was much slower but greater in total than from PAA/QU/β-CD-IC-film. Moreover, high antioxidant activity and photostability of QU was achieved in PAA/QU/β-CD-IC-NF.

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Keywords
Antioxidant activity, Electrospinning, Modelling, Nanofibres, Phase solubility, Photostability, Polyacrylic acid, Quercetin, β-Cyclodextrin, Antioxidants, Complexation, Cyclodextrins, Electrospinning, Flavonoids, Models, Organic acids, Phenols, Solubility, Spinning (fibers), Anti-oxidant activities, Phase solubility, Photo-stability, Polyacrylic acids, Quercetin, Nanofibers, 2,2-diphenyl-1-picrylhydrazyl, Antioxidant, Beta cyclodextrin, Beta cyclodextrin derivative, Biphenyl derivative, Drug carrier, Nanofiber, Picric acid, Quercetin, Chemical structure, Chemistry, Drug formulation, Drug release, Drug stability, Particle size, Scanning electron microscopy, Solubility, Surface property, X ray diffraction, Antioxidants, Beta-Cyclodextrins, Biphenyl Compounds, Drug Carriers, Drug Compounding, Drug Liberation, Drug Stability, Microscopy, Electron, Scanning, Models, Molecular, Nanofibers, Particle Size, Picrates, Quercetin, Solubility, Surface Properties, X-Ray Diffraction
Citation
Published Version (Please cite this version)