Nanomaterials for neural regeneration

Date
2016-03-11
Advisor
Instructor
Source Title
Print ISSN
Electronic ISSN
Publisher
John Wiley & Sons
Volume
Issue
Pages
33 - 58
Language
English
Type
Book Chapter
Journal Title
Journal ISSN
Volume Title
Abstract

The central nervous system (CNS) consists of a dense network of cells leaving a smaller volume for the extracellular matrix (ECM) components (10‐20% for the brain unlike most other tissues (Cragg, 1979)). The reaction of the nervous tissue to any injury leading to scar tissue formation acts as a barrier for regeneration in the CNS, while it supports regeneration in the peripheral nervous system (PNS). By mimicking several unique characteristics of the natural environment of cells, synthetic materials for neural regeneration can be improved chemically and biologically. Especially bioactivation of materials can be achieved by addition of small chemical moieties to the scaffold particularly found in specific tissues or addition of biologically active molecules derived from natural ECM. The ECM‐derived short peptides are promising candidates to be presented as functional domains on the scaffold surface for use in neural regeneration.

Course
Other identifiers
Book Title
Therapeutic nanomaterials
Keywords
Biological functionalization, Cellular behavior, Central nervous system, Chemical functionalization, Electrical conductivity, Extracellular matrix, Nanomaterials, Neural regeneration, Peripheral nervous system
Citation