DNA repair gene polymorphisms and bladder cancer susceptibility in a Turkish population

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dc.citation.epage4958en_US
dc.citation.issueNumber6 Cen_US
dc.citation.spage4955en_US
dc.citation.volumeNumber26en_US
dc.contributor.authorKarahalil, B.en_US
dc.contributor.authorKocabas, N. A.en_US
dc.contributor.authorÖzçelik, T.en_US
dc.date.accessioned2016-02-08T10:17:30Z
dc.date.available2016-02-08T10:17:30Z
dc.date.issued2006en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractBackground: Occupational exposure and life style preferences, such as smoking are the main known environmental susceptibility factors for bladder cancer. A growing list of chemicals has been shown to induce oxidative DNA damage. Base excision repair (BER) genes (X-ray repair cross complementing 1, XRCC1 and human 8-oxoguanine DNA glycosylase 1, OGG1) may play a key role in maintaining genome integrity and preventing cancer development. Materials and Methods: We tested whether polymorphisms in XRCC1 and OGG1 are associated with bladder cancer risk by using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) assay. In addition, the possible modifying affect of cigarette smoking was evaluated. Results: No studies, to date, have examined the association between genetic polymorphisms in DNA repair genes and bladder cancer susceptibility, in the Turkish population. We found the OGG1 Cys326Cys genotype to be more frequent among bladder cancer patients (odds ratio (OR): 2.41 (95% CI, 1.36-4.25)). However, in the case of XRCC1, there was no significant difference in susceptibility to bladder cancer development between patients with the Arg399 and these with the Gln399 allele (OR: 0.72 (95% CI, 0.41-1.26)). Conclusion: Our data showed that OGG1 genetic polymorphisms might be useful as prognostic genetic markers for bladder cancer in the clinical setting.en_US
dc.identifier.issn0250-7005
dc.identifier.urihttp://hdl.handle.net/11693/23684
dc.language.isoEnglishen_US
dc.publisherInternational Institute of Anticancer Researchen_US
dc.source.titleAnticancer Researchen_US
dc.subjectArg399Glnen_US
dc.subjectBladder canceren_US
dc.subjectCigarette smokingen_US
dc.subjectOGGen_US
dc.subjectPolymorphismen_US
dc.subjectSer326Cysen_US
dc.subjectTurkish populationen_US
dc.subjectXRCC1en_US
dc.subjectArginineen_US
dc.subjectCysteineen_US
dc.subjectGlutamineen_US
dc.subjectNuclear proteinen_US
dc.subjectProtein 8 oxoguanine dna glycosylase 1en_US
dc.subjectProtein x ray repair cross complementing 1en_US
dc.subjectUnclassified drugen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectArticleen_US
dc.subjectBladder canceren_US
dc.subjectCancer risken_US
dc.subjectCancer susceptibilityen_US
dc.subjectCigarette smokingen_US
dc.subjectControlled studyen_US
dc.subjectDNA polymorphismen_US
dc.subjectDNA repairen_US
dc.subjectExcision repairen_US
dc.subjectGene frequencyen_US
dc.subjectGenetic analysisen_US
dc.subjectHumanen_US
dc.subjectMajor clinical studyen_US
dc.subjectPolymerase chain reactionen_US
dc.subjectPriority journalen_US
dc.subjectRestriction fragment length polymorphismen_US
dc.subjectTurkey (republic)en_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAged, 80 and overen_US
dc.subjectDNA Glycosylasesen_US
dc.subjectDNA Repairen_US
dc.subjectDNA-Binding Proteinsen_US
dc.subjectGenetic predisposition to diseaseen_US
dc.subjectHumansen_US
dc.subjectMiddle Ageden_US
dc.subjectPolymerase Chain Reactionen_US
dc.subjectPolymorphism, Geneticen_US
dc.subjectPolymorphism, Restriction fragment lengthen_US
dc.subjectTurkeyen_US
dc.subjectUrinary bladder neoplasmsen_US
dc.titleDNA repair gene polymorphisms and bladder cancer susceptibility in a Turkish populationen_US
dc.typeArticleen_US

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Department of Molecular Biology and Genetics
Institute of Materials Science and Nanotechnology (UNAM)