DNA repair gene polymorphisms and bladder cancer susceptibility in a Turkish population

Date
2006
Authors
Karahalil, B.
Kocabas, N. A.
Özçelik, T.
Advisor
Instructor
Source Title
Anticancer Research
Print ISSN
0250-7005
Electronic ISSN
Publisher
International Institute of Anticancer Research
Volume
26
Issue
6 C
Pages
4955 - 4958
Language
English
Type
Article
Journal Title
Journal ISSN
Volume Title
Abstract

Background: Occupational exposure and life style preferences, such as smoking are the main known environmental susceptibility factors for bladder cancer. A growing list of chemicals has been shown to induce oxidative DNA damage. Base excision repair (BER) genes (X-ray repair cross complementing 1, XRCC1 and human 8-oxoguanine DNA glycosylase 1, OGG1) may play a key role in maintaining genome integrity and preventing cancer development. Materials and Methods: We tested whether polymorphisms in XRCC1 and OGG1 are associated with bladder cancer risk by using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) assay. In addition, the possible modifying affect of cigarette smoking was evaluated. Results: No studies, to date, have examined the association between genetic polymorphisms in DNA repair genes and bladder cancer susceptibility, in the Turkish population. We found the OGG1 Cys326Cys genotype to be more frequent among bladder cancer patients (odds ratio (OR): 2.41 (95% CI, 1.36-4.25)). However, in the case of XRCC1, there was no significant difference in susceptibility to bladder cancer development between patients with the Arg399 and these with the Gln399 allele (OR: 0.72 (95% CI, 0.41-1.26)). Conclusion: Our data showed that OGG1 genetic polymorphisms might be useful as prognostic genetic markers for bladder cancer in the clinical setting.

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Keywords
Arg399Gln, Bladder cancer, Cigarette smoking, OGG, Polymorphism, Ser326Cys, Turkish population, XRCC1, Arginine, Cysteine, Glutamine, Nuclear protein, Protein 8 oxoguanine dna glycosylase 1, Protein x ray repair cross complementing 1, Unclassified drug, Adult, Aged, Article, Bladder cancer, Cancer risk, Cancer susceptibility, Cigarette smoking, Controlled study, DNA polymorphism, DNA repair, Excision repair, Gene frequency, Genetic analysis, Human, Major clinical study, Polymerase chain reaction, Priority journal, Restriction fragment length polymorphism, Turkey (republic), Adult, Aged, Aged, 80 and over, DNA Glycosylases, DNA Repair, DNA-Binding Proteins, Genetic predisposition to disease, Humans, Middle Aged, Polymerase Chain Reaction, Polymorphism, Genetic, Polymorphism, Restriction fragment length, Turkey, Urinary bladder neoplasms
Citation
Published Version (Please cite this version)