Antigenic GM3 lactone mimetic molecule integrated mannosylated glycopeptide nanofibers for the activation and maturation of dendritic cells
buir.contributor.author | Gunay, Gokhan | |
buir.contributor.author | Ekiz, Melis Sardan | |
buir.contributor.author | Tekinay, Ayse B. | |
buir.contributor.author | Güler, Mustafa O. | |
dc.citation.epage | 16042 | en_US |
dc.citation.issueNumber | 19 | en_US |
dc.citation.spage | 16035 | en_US |
dc.citation.volumeNumber | 9 | en_US |
dc.contributor.author | Gunay, Gokhan | en_US |
dc.contributor.author | Ekiz, Melis Sardan | en_US |
dc.contributor.author | Ferhati, X. | en_US |
dc.contributor.author | Richichi, B. | en_US |
dc.contributor.author | Nativi, C. | en_US |
dc.contributor.author | Tekinay, Ayse B. | en_US |
dc.contributor.author | Güler, Mustafa O. | en_US |
dc.date.accessioned | 2018-04-12T11:08:39Z | |
dc.date.available | 2018-04-12T11:08:39Z | |
dc.date.issued | 2017 | en_US |
dc.department | Interdisciplinary Program in Neuroscience (NEUROSCIENCE) | en_US |
dc.department | Institute of Materials Science and Nanotechnology (UNAM) | en_US |
dc.department | Aysel Sabuncu Brain Research Center (BAM) | en_US |
dc.description.abstract | The ability of dendritic cells to coordinate innate and adaptive immune responses makes them essential targets for vaccination strategies. Presentation of specific antigens by dendritic cells is required for the activation of the immune system against many pathogens and tumors, and nanoscale materials can be functionalized for active targeting of dendritic cells. In this work, we integrated an immunogenic, carbohydrate melanoma-associated antigen-mimetic GM3-lactone molecule into mannosylated peptide amphiphile nanofibers to target dendritic cells through DC-SIGN receptor. Based on morphological and functional analyses, when dendritic cells were treated with peptide nanofiber carriers, they showed significant increase in antigen internalization and a corresponding increase in the surface expression of the activation and maturation markers CD86, CD83 and HLA-DR, in addition to exhibiting a general morphology consistent with dendritic cell maturation. These results indicate that mannosylated peptide amphiphile nanofiber carriers are promising candidates to target dendritic cells for antigen delivery. © 2017 American Chemical Society. | en_US |
dc.description.provenance | Made available in DSpace on 2018-04-12T11:08:39Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2017 | en |
dc.identifier.doi | 10.1021/acsami.7b04094 | en_US |
dc.identifier.issn | 1944-8244 | |
dc.identifier.uri | http://hdl.handle.net/11693/37285 | |
dc.language.iso | English | en_US |
dc.publisher | American Chemical Society | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1021/acsami.7b04094 | en_US |
dc.source.title | ACS Applied Materials and Interfaces | en_US |
dc.subject | Cancer antigens | en_US |
dc.subject | Carbohydrate melanoma associated antigen | en_US |
dc.subject | Dendritic cells | en_US |
dc.subject | Amphiphiles | en_US |
dc.subject | Antigens | en_US |
dc.subject | Biomimetics | en_US |
dc.subject | Carbohydrates | en_US |
dc.subject | Chemical activation | en_US |
dc.subject | Cytology | en_US |
dc.subject | Dermatology | en_US |
dc.subject | Diseases | en_US |
dc.subject | Esters | en_US |
dc.subject | Immune system | en_US |
dc.subject | Molecules | en_US |
dc.subject | Nanofibers | en_US |
dc.subject | Oncology | en_US |
dc.subject | Peptides | en_US |
dc.subject | Polypeptides | en_US |
dc.subject | Adaptive immune response | en_US |
dc.subject | Antigen delivery | en_US |
dc.subject | Cancer immunotherapy | en_US |
dc.subject | Dendritic cells | en_US |
dc.subject | Nano-scale materials | en_US |
dc.subject | Peptide amphiphiles | en_US |
dc.subject | Surface expression | en_US |
dc.subject | Vaccination strategy | en_US |
dc.subject | Cells | en_US |
dc.title | Antigenic GM3 lactone mimetic molecule integrated mannosylated glycopeptide nanofibers for the activation and maturation of dendritic cells | en_US |
dc.type | Article | en_US |
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