Polymer-free electrospun nanofibers from sulfobutyl ether7-beta-cyclodextrin (SBE7-β-CD) inclusion complex with sulfisoxazole: fast-dissolving and enhanced water-solubility of sulfisoxazole

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buir.contributor.authorUyar, Tamer
buir.contributor.orcidUyar, Tamer|0000-0002-3989-4481
dc.citation.epage558en_US
dc.citation.issueNumber2en_US
dc.citation.spage550en_US
dc.citation.volumeNumber531en_US
dc.contributor.authorYildiz, Z. I.en_US
dc.contributor.authorCelebioglu A.en_US
dc.contributor.authorUyar, Tameren_US
dc.date.accessioned2018-04-12T11:11:49Z
dc.date.available2018-04-12T11:11:49Z
dc.date.issued2017-10en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractIn this study, our aim was to develop solid drug-cyclodextrin inclusion complex system having nanofibrous morphology in order to have fast-dissolving property and enhanced water-solubility of poorly water-soluble drug. Here, we prepared a highly concentrated aqueous solution of inclusion complex between sulfisoxazole and sulfobutyl ether7-beta-cyclodextrin (SBE7-β-CD, Captisol®), and then, without using any polymeric matrix, the electrospinning of sulfisoxazole/SBE7-β-CD-IC nanofibers was performed in order to obtain free-standing and handy nanofibrous web. As a control sample, nanofibers from pure SBE7-β-CD was also electrospun and free-standing nanofibrous web was obtained. The SEM imaging revealed that the bead-free and uniform nanofiber morphology with the average fiber diameter (AFD) of 650 ± 290 nm for sulfisoxazole/SBE7-β-CD-IC NF and 890 ± 415 nm for pure SBE7-β-CD NF was obtained. The inclusion complex formation between sulfisoxazole and SBE7-β-CD in sulfisoxazole/SBE7-β-CD-IC NF sample was confirmed by 1H NMR, TGA, DSC, XRD and FTIR analyses. Due to the combined advantage of cyclodextrin inclusion complexation and high surface area of electrospun nanofibers, fast-dissolving property with enhanced water-solubility was successfully achieved for sulfisoxazole/SBE7-β-CD-IC NF. Our findings suggest that electrospun nanofibers/nanowebs from CD-IC of poorly water-soluble drugs may offer applicable approaches for high water-solubility and fast-dissolving tablet formulations for drug delivery systems.en_US
dc.identifier.doi10.1016/j.ijpharm.2017.04.047en_US
dc.identifier.issn0378-5173
dc.identifier.urihttp://hdl.handle.net/11693/37380
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttps://doi.org/10.1016/j.ijpharm.2017.04.047en_US
dc.source.titleInternational Journal of Pharmaceuticsen_US
dc.subjectElectrospinningen_US
dc.subjectElectrospun nanofibersen_US
dc.subjectInclusion complexen_US
dc.subjectSulfisoxazoleen_US
dc.subjectSulfobutyl ether7-beta-cyclodextrin (Captisol®)en_US
dc.subjectWater-Solubilityen_US
dc.subjectBeta cyclodextrin sulfobutyl etheren_US
dc.subjectNanofiberen_US
dc.subjectPolymeren_US
dc.subjectSulfafurazoleen_US
dc.subjectWateren_US
dc.subjectBeta cyclodextrin derivativeen_US
dc.subjectDrug carrieren_US
dc.titlePolymer-free electrospun nanofibers from sulfobutyl ether7-beta-cyclodextrin (SBE7-β-CD) inclusion complex with sulfisoxazole: fast-dissolving and enhanced water-solubility of sulfisoxazoleen_US
dc.typeArticleen_US

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Institute of Materials Science and Nanotechnology (UNAM)
Nanotechnology Research Center (NANOTAM)