Angiogenic peptide nanofibers improve wound healing in STZ-induced diabetic rats

buir.contributor.authorGüler, Mustafa O.
dc.citation.epage1189en_US
dc.citation.issueNumber7en_US
dc.citation.spage1180en_US
dc.citation.volumeNumber2en_US
dc.contributor.authorSenturk, B.en_US
dc.contributor.authorMercan, S.en_US
dc.contributor.authorDelibasi, T.en_US
dc.contributor.authorGüler, Mustafa O.en_US
dc.contributor.authorTekinay, A. B.en_US
dc.date.accessioned2018-04-12T10:50:51Z
dc.date.available2018-04-12T10:50:51Z
dc.date.issued2016-06en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractLow expressions of angiogenic growth factors delay the healing of diabetic wounds by interfering with the process of blood vessel formation. Heparin mimetic peptide nanofibers can bind to and enhance production and activity of major angiogenic growth factors, including VEGF. In this study, we showed that heparin mimetic peptide nanofibers can serve as angiogenic scaffolds that allow slow release of growth factors and protect them from degradation, providing a new therapeutic way to accelerate healing of diabetic wounds. We treated wounds in STZ-induced diabetic rats with heparin mimetic peptide nanofibers and studied repair of full-thickness diabetic skin wounds. Wound recovery was quantified by analyses of re-epithelialization, granulation tissue formation and blood vessel density, as well as VEGF and inflammatory response measurements. Wound closure and granulation tissue formation were found to be significantly accelerated in heparin mimetic gel treated groups. In addition, blood vessel counts and the expressions of alpha smooth muscle actin and VEGF were significantly higher in bioactive gel treated animals. These results strongly suggest that angiogenic heparin mimetic nanofiber therapy can be used to support the impaired healing process in diabetic wounds.en_US
dc.description.provenanceMade available in DSpace on 2018-04-12T10:50:51Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2016en
dc.identifier.doi10.1021/acsbiomaterials.6b00238en_US
dc.identifier.issn2373-9878
dc.identifier.urihttp://hdl.handle.net/11693/36723
dc.language.isoEnglishen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionofhttps://doi.org/10.1021/acsbiomaterials.6b00238en_US
dc.source.titleACS Biomaterials Science and Engineeringen_US
dc.subjectAngiogenesisen_US
dc.subjectDiabetic wound healingen_US
dc.subjectHeparin mimeticen_US
dc.subjectPeptide amphiphilesen_US
dc.subjectVEGF expressionen_US
dc.subjectAlpha smooth muscle actinen_US
dc.subjectAngiogenesis inhibitoren_US
dc.subjectGrowth factoren_US
dc.subjectHeparin derivativeen_US
dc.subjectHeparin mimetic peptideen_US
dc.subjectNanofiberen_US
dc.subjectStreptozocinen_US
dc.subjectUnclassified drugen_US
dc.subjectVasculotropinen_US
dc.subjectAnimal experimenten_US
dc.subjectAnimal tissueen_US
dc.subjectAntiangiogenic therapyen_US
dc.subjectArticleen_US
dc.subjectBlood vesselen_US
dc.subjectCapillary densityen_US
dc.subjectControlled studyen_US
dc.subjectDiabetic wounden_US
dc.subjectDiabetic wounden_US
dc.subjectEpithelizationen_US
dc.subjectGelen_US
dc.subjectGranulation tissueen_US
dc.subjectInflammationen_US
dc.subjectMaleen_US
dc.subjectNonhumanen_US
dc.subjectPriority journalen_US
dc.subjectProtein degradationen_US
dc.subjectProtein expressionen_US
dc.subjectRaten_US
dc.subjectSkinen_US
dc.subjectSkinfold thicknessen_US
dc.subjectStreptozotocin-induced diabetes mellitusen_US
dc.subjectWounden_US
dc.subjectWound closureen_US
dc.subjectWound healingen_US
dc.titleAngiogenic peptide nanofibers improve wound healing in STZ-induced diabetic ratsen_US
dc.typeArticleen_US

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