Protein-releasing conductive anodized alumina membranes for nerve-interface materials
buir.contributor.author | Bıyıklı, Necmi | |
dc.citation.epage | 598 | en_US |
dc.citation.spage | 590 | en_US |
dc.citation.volumeNumber | 67 | en_US |
dc.contributor.author | Altuntas, S. | en_US |
dc.contributor.author | Buyukserin, F. | en_US |
dc.contributor.author | Haider, A. | en_US |
dc.contributor.author | Altinok, B. | en_US |
dc.contributor.author | Bıyıklı, Necmi | en_US |
dc.contributor.author | Aslim, B. | en_US |
dc.date.accessioned | 2018-04-12T10:53:54Z | |
dc.date.available | 2018-04-12T10:53:54Z | |
dc.date.issued | 2016 | en_US |
dc.department | Institute of Materials Science and Nanotechnology (UNAM) | en_US |
dc.description.abstract | Nanoporous anodized alumina membranes (AAMs) have numerous biomedical applications spanning from biosensors to controlled drug delivery and implant coatings. Although the use of AAM as an alternative bone implant surface has been successful, its potential as a neural implant coating remains unclear. Here, we introduce conductive and nerve growth factor-releasing AAM substrates that not only provide the native nanoporous morphology for cell adhesion, but also induce neural differentiation. We recently reported the fabrication of such conductive membranes by coating AAMs with a thin C layer. In this study, we investigated the influence of electrical stimulus, surface topography, and chemistry on cell adhesion, neurite extension, and density by using PC 12 pheochromocytoma cells in a custom-made glass microwell setup. The conductive AAMs showed enhanced neurite extension and generation with the electrical stimulus, but cell adhesion on these substrates was poorer compared to the naked AAMs. The latter nanoporous material presents chemical and topographical features for superior neuronal cell adhesion, but, more importantly, when loaded with nerve growth factor, it can provide neurite extension similar to an electrically stimulated CAAM counterpart. | en_US |
dc.description.provenance | Made available in DSpace on 2018-04-12T10:53:54Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2016 | en |
dc.identifier.doi | 10.1016/j.msec.2016.05.084 | en_US |
dc.identifier.issn | 0928-4931 | |
dc.identifier.uri | http://hdl.handle.net/11693/36803 | |
dc.language.iso | English | en_US |
dc.publisher | Elsevier Ltd | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1016/j.msec.2016.05.084 | en_US |
dc.source.title | Materials Science and Engineering C: Materials for Biological Applications | en_US |
dc.subject | Alumina membranes | en_US |
dc.subject | Biomaterials | en_US |
dc.subject | Electrical stimulation | en_US |
dc.subject | Nanotechnology | en_US |
dc.subject | PC12 cells | en_US |
dc.subject | Alumina | en_US |
dc.subject | Biomaterials | en_US |
dc.subject | Cell adhesion | en_US |
dc.subject | Cells | en_US |
dc.subject | Coatings | en_US |
dc.subject | Controlled drug delivery | en_US |
dc.subject | Cytology | en_US |
dc.subject | Interfaces (materials) | en_US |
dc.subject | Medical applications | en_US |
dc.subject | Membranes | en_US |
dc.subject | Nanopores | en_US |
dc.subject | Nanotechnology | en_US |
dc.subject | Neurons | en_US |
dc.subject | Porous materials | en_US |
dc.subject | Surface topography | en_US |
dc.subject | Alumina membranes | en_US |
dc.subject | Anodized alumina membranes | en_US |
dc.subject | Biomedical applications | en_US |
dc.subject | Electrical stimulations | en_US |
dc.subject | Nanoporous morphologies | en_US |
dc.subject | Neural differentiations | en_US |
dc.subject | PC-12 cells | en_US |
dc.subject | PC-12 pheochromocytoma cells | en_US |
dc.subject | Conductive materials | en_US |
dc.subject | Aluminum oxide | en_US |
dc.subject | Artificial membrane | en_US |
dc.subject | Delayed release formulation | en_US |
dc.subject | Nerve growth factor | en_US |
dc.subject | Animal | en_US |
dc.subject | Artificial membrane | en_US |
dc.subject | Cell adhesion | en_US |
dc.subject | Chemistry | en_US |
dc.subject | Delayed release formulation | en_US |
dc.subject | Drug effects | en_US |
dc.subject | Electric conductivity | en_US |
dc.subject | PC12 cell line | en_US |
dc.subject | Pharmacokinetics | en_US |
dc.subject | Pharmacology | en_US |
dc.subject | Rat | en_US |
dc.subject | Aluminum oxide | en_US |
dc.subject | Animals | en_US |
dc.subject | Cell adhesion | en_US |
dc.subject | Delayed-action preparations | en_US |
dc.subject | Electric conductivity | en_US |
dc.subject | Membranes, artificial | en_US |
dc.subject | Nerve growth factor | en_US |
dc.subject | PC12 cells | en_US |
dc.subject | Rats | en_US |
dc.title | Protein-releasing conductive anodized alumina membranes for nerve-interface materials | en_US |
dc.type | Article | en_US |
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