Spectroscopic evaluation of DNA–borate Interactions

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dc.citation.epage515en_US
dc.citation.issueNumber2en_US
dc.citation.spage508en_US
dc.citation.volumeNumber168en_US
dc.contributor.authorOzdemir, A.en_US
dc.contributor.authorSarioglu O. F.en_US
dc.contributor.authorTekinay, T.en_US
dc.date.accessioned2016-02-08T10:55:41Z
dc.date.available2016-02-08T10:55:41Z
dc.date.issued2015en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractWe describe the binding characteristics of two natural borates (colemanite and ulexite) to calf thymus DNA by UV–vis absorbance spectroscopy, circular dichroism (CD) spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, and a competitive DNA binding assay. Our results suggest that colemanite and ulexite interact with calf thymus DNA under a non-intercalative mode of binding and do not alter the secondary structure of the DNA helix. The FT-IR spectroscopy results indicate that the two borates might interact with DNA through sugar-phosphate backbone binding. © 2015, Springer Science+Business Media New York.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T10:55:41Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2015en
dc.identifier.doi10.1007/s12011-015-0369-5en_US
dc.identifier.issn0163-4984
dc.identifier.urihttp://hdl.handle.net/11693/26146
dc.language.isoEnglishen_US
dc.publisherHumana Press Inc.en_US
dc.relation.isversionofhttps://doi.org/10.1007/s12011-015-0369-5en_US
dc.source.titleBiological Trace Element Researchen_US
dc.subjectBoronen_US
dc.subjectCalf thymus DNAen_US
dc.subjectDeoxyribose sugaren_US
dc.subjectDNA bindingen_US
dc.subjectSpectroscopyen_US
dc.subjectBoric aciden_US
dc.subjectColemaniteen_US
dc.subjectDNAen_US
dc.subjectSugar phosphateen_US
dc.subjectUlexiteen_US
dc.subjectUnclassified drugen_US
dc.subjectChemical structureen_US
dc.subjectCircular dichroismen_US
dc.subjectCompetitive binding assayen_US
dc.subjectControlled studyen_US
dc.subjectDNA helixen_US
dc.subjectDNA structureen_US
dc.subjectInfrared spectroscopyen_US
dc.subjectInteractions with DNAen_US
dc.subjectUltraviolet spectroscopyen_US
dc.titleSpectroscopic evaluation of DNA–borate Interactionsen_US
dc.typeArticleen_US

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