Spectroscopic evaluation of DNA–borate Interactions

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Spectroscopic-Evaluation-of-DNA–Borate-Interactions.pdf (1.64 MB)

Date

2015

Authors

Ozdemir, A.
Sarioglu O. F.
Tekinay, T.

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Abstract

We describe the binding characteristics of two natural borates (colemanite and ulexite) to calf thymus DNA by UV–vis absorbance spectroscopy, circular dichroism (CD) spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, and a competitive DNA binding assay. Our results suggest that colemanite and ulexite interact with calf thymus DNA under a non-intercalative mode of binding and do not alter the secondary structure of the DNA helix. The FT-IR spectroscopy results indicate that the two borates might interact with DNA through sugar-phosphate backbone binding. © 2015, Springer Science+Business Media New York.

Source Title

Biological Trace Element Research

Publisher

Humana Press Inc.

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Keywords

Boron, Calf thymus DNA, Deoxyribose sugar, DNA binding, Spectroscopy, Boric acid, Colemanite, DNA, Sugar phosphate, Ulexite, Unclassified drug, Chemical structure, Circular dichroism, Competitive binding assay, Controlled study, DNA helix, DNA structure, Infrared spectroscopy, Interactions with DNA, Ultraviolet spectroscopy

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http://hdl.handle.net/11693/26146

Published Version (Please cite this version)

https://doi.org/10.1007/s12011-015-0369-5

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Scholarly Publications - UNAM
Scholarly Publications - NANOTAM

Language

English

Type

Article