Fast-dissolving, prolonged release, and antibacterial cyclodextrin/limonene-inclusion complex nanofibrous webs via polymer-free electrospinning

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buir.contributor.authorUyar, Tamer
buir.contributor.authorDurgun, Engin
buir.contributor.orcidUyar, Tamer|0000-0002-3989-4481
dc.citation.epage7334en_US
dc.citation.issueNumber39en_US
dc.citation.spage7325en_US
dc.citation.volumeNumber64en_US
dc.contributor.authorAytac Z.en_US
dc.contributor.authorYildiz, Z. I.en_US
dc.contributor.authorKayaci-Senirmak, F.en_US
dc.contributor.authorS. Keskin, N. O.en_US
dc.contributor.authorKusku, S. I.en_US
dc.contributor.authorDurgun, Enginen_US
dc.contributor.authorTekinay, T.en_US
dc.contributor.authorUyar, Tameren_US
dc.date.accessioned2018-04-12T10:51:50Z
dc.date.available2018-04-12T10:51:50Z
dc.date.issued2016en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractWe have proposed a new strategy for preparing free-standing nanofibrous webs from an inclusion complex (IC) of a well-known flavor/fragrance compound (limonene) with three modified cyclodextrins (HPβCD, MβCD, and HPγCD) via electrospinning (CD/limonene-IC-NFs) without using a polymeric matrix. The experimental and computational modeling studies proved that the stoichiometry of the complexes was 1:1 for CD/limonene systems. MβCD/limonene-IC-NF released much more limonene at 37, 50, and 75 °C than HPβCD/limonene-IC-NF and HPγCD/limonene-IC-NF because of the greater amount of preserved limonene. Moreover, MβCD/limonene-IC-NF has released only 25% (w/w) of its limonene, whereas HPβCD/limonene-IC-NF and HPγCD/limonene-IC-NF released 51 and 88% (w/w) of their limonene in 100 days, respectively. CD/limonene-IC-NFs exhibited high antibacterial activity against E. coli and S. aureus. The water solubility of limonene increased significantly and CD/limonene-IC-NFs were dissolved in water in a few seconds. In brief, CD/limonene-IC-NFs with fast-dissolving character enhanced the thermal stability and prolonged the shelf life along with antibacterial properties could be quite applicable in food and oral care applications.en_US
dc.description.provenanceMade available in DSpace on 2018-04-12T10:51:50Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2016en
dc.identifier.doi10.1021/acs.jafc.6b02632en_US
dc.identifier.issn0021-8561
dc.identifier.urihttp://hdl.handle.net/11693/36745
dc.language.isoEnglishen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionofhttps://doi.org/10.1021/acs.jafc.6b02632en_US
dc.source.titleJournal of Agricultural and Food Chemistryen_US
dc.subjectAntibacterial activityen_US
dc.subjectComputational modelingen_US
dc.subjectElectrospinningen_US
dc.subjectEssential oilen_US
dc.subjectModified cyclodextrinsen_US
dc.subjectComputation theoryen_US
dc.subjectCyclodextrinsen_US
dc.subjectElectrospinningen_US
dc.subjectEscherichia colien_US
dc.subjectEssential oilsen_US
dc.subjectFlavor compoundsen_US
dc.subjectMonoterpenesen_US
dc.subjectNanofibersen_US
dc.subjectOils and fatsen_US
dc.subjectPolymersen_US
dc.subjectSpinning (fibers)en_US
dc.subjectAnti-bacterial activityen_US
dc.subjectAntibacterial propertiesen_US
dc.subjectComputational modelen_US
dc.subjectInclusion complexen_US
dc.subjectModified cyclodextrinsen_US
dc.subjectPolymeric matricesen_US
dc.subjectProlonged releaseen_US
dc.subjectWater solubilitiesen_US
dc.subjectDissolutionen_US
dc.subjectAntiinfective agenten_US
dc.subjectCyclodextrinen_US
dc.subjectCyclohexene derivativeen_US
dc.subjectDrug carrieren_US
dc.subjectEssential oilen_US
dc.subjectLimoneneen_US
dc.subjectNanofiberen_US
dc.subjectTerpeneen_US
dc.subjectChemistryen_US
dc.subjectDrug effectsen_US
dc.subjectDrug releaseen_US
dc.subjectDrug stabilityen_US
dc.subjectEscherichia colien_US
dc.subjectMolecular computeren_US
dc.subjectNuclear magnetic resonance spectroscopyen_US
dc.subjectParticle sizeen_US
dc.subjectScanning electron microscopyen_US
dc.subjectSolubilityen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectThermogravimetryen_US
dc.subjectX ray crystallographyen_US
dc.subjectAnti-Bacterial Agentsen_US
dc.subjectComputers, Molecularen_US
dc.subjectCrystallography, X-Rayen_US
dc.subjectCyclodextrinsen_US
dc.subjectCyclohexenesen_US
dc.subjectDrug Carriersen_US
dc.subjectDrug Liberationen_US
dc.subjectDrug Stabilityen_US
dc.subjectEscherichia colien_US
dc.subjectMagnetic Resonance Spectroscopyen_US
dc.subjectMicroscopy, Electron, Scanningen_US
dc.subjectNanofibersen_US
dc.subjectOils, Volatileen_US
dc.subjectParticle Sizeen_US
dc.subjectSolubilityen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectTerpenesen_US
dc.subjectThermogravimetryen_US
dc.titleFast-dissolving, prolonged release, and antibacterial cyclodextrin/limonene-inclusion complex nanofibrous webs via polymer-free electrospinningen_US
dc.typeArticleen_US

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