Fast-dissolving, prolonged release, and antibacterial cyclodextrin/limonene-inclusion complex nanofibrous webs via polymer-free electrospinning

We have proposed a new strategy for preparing free-standing nanofibrous webs from an inclusion complex (IC) of a well-known flavor/fragrance compound (limonene) with three modified cyclodextrins (HPβCD, MβCD, and HPγCD) via electrospinning (CD/limonene-IC-NFs) without using a polymeric matrix. The experimental and computational modeling studies proved that the stoichiometry of the complexes was 1:1 for CD/limonene systems. MβCD/limonene-IC-NF released much more limonene at 37, 50, and 75 °C than HPβCD/limonene-IC-NF and HPγCD/limonene-IC-NF because of the greater amount of preserved limonene. Moreover, MβCD/limonene-IC-NF has released only 25% (w/w) of its limonene, whereas HPβCD/limonene-IC-NF and HPγCD/limonene-IC-NF released 51 and 88% (w/w) of their limonene in 100 days, respectively. CD/limonene-IC-NFs exhibited high antibacterial activity against E. coli and S. aureus. The water solubility of limonene increased significantly and CD/limonene-IC-NFs were dissolved in water in a few seconds. In brief, CD/limonene-IC-NFs with fast-dissolving character enhanced the thermal stability and prolonged the shelf life along with antibacterial properties could be quite applicable in food and oral care applications.

Keywords

Antibacterial activity, Computational modeling, Electrospinning, Essential oil, Modified cyclodextrins, Computation theory, Cyclodextrins, Electrospinning, Escherichia coli, Essential oils, Flavor compounds, Monoterpenes, Nanofibers, Oils and fats, Polymers, Spinning (fibers), Anti-bacterial activity, Antibacterial properties, Computational model, Inclusion complex, Modified cyclodextrins, Polymeric matrices, Prolonged release, Water solubilities, Dissolution, Antiinfective agent, Cyclodextrin, Cyclohexene derivative, Drug carrier, Essential oil, Limonene, Nanofiber, Terpene, Chemistry, Drug effects, Drug release, Drug stability, Escherichia coli, Molecular computer, Nuclear magnetic resonance spectroscopy, Particle size, Scanning electron microscopy, Solubility, Staphylococcus aureus, Thermogravimetry, X ray crystallography, Anti-Bacterial Agents, Computers, Molecular, Crystallography, X-Ray, Cyclodextrins, Cyclohexenes, Drug Carriers, Drug Liberation, Drug Stability, Escherichia coli, Magnetic Resonance Spectroscopy, Microscopy, Electron, Scanning, Nanofibers, Oils, Volatile, Particle Size, Solubility, Staphylococcus aureus, Terpenes, Thermogravimetry

Fast-dissolving, prolonged release, and antibacterial cyclodextrin/limonene-inclusion complex nanofibrous webs via polymer-free electrospinning

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