Fast-dissolving, prolonged release, and antibacterial cyclodextrin/limonene-inclusion complex nanofibrous webs via polymer-free electrospinning

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Fast-Dissolving Prolonged Release and Antibacterial CyclodextrinLimonene-Inclusion Complex Nanofibrous Webs via Polymer-Free Electrospinning.pdf (5.89 MB)

Date

2016

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Source Title

Journal of Agricultural and Food Chemistry

Print ISSN

0021-8561

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Publisher

American Chemical Society

Volume

64

Issue

39

Pages

7325 - 7334

Language

English

Type

Article

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Abstract

We have proposed a new strategy for preparing free-standing nanofibrous webs from an inclusion complex (IC) of a well-known flavor/fragrance compound (limonene) with three modified cyclodextrins (HPβCD, MβCD, and HPγCD) via electrospinning (CD/limonene-IC-NFs) without using a polymeric matrix. The experimental and computational modeling studies proved that the stoichiometry of the complexes was 1:1 for CD/limonene systems. MβCD/limonene-IC-NF released much more limonene at 37, 50, and 75 °C than HPβCD/limonene-IC-NF and HPγCD/limonene-IC-NF because of the greater amount of preserved limonene. Moreover, MβCD/limonene-IC-NF has released only 25% (w/w) of its limonene, whereas HPβCD/limonene-IC-NF and HPγCD/limonene-IC-NF released 51 and 88% (w/w) of their limonene in 100 days, respectively. CD/limonene-IC-NFs exhibited high antibacterial activity against E. coli and S. aureus. The water solubility of limonene increased significantly and CD/limonene-IC-NFs were dissolved in water in a few seconds. In brief, CD/limonene-IC-NFs with fast-dissolving character enhanced the thermal stability and prolonged the shelf life along with antibacterial properties could be quite applicable in food and oral care applications.

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Keywords

Antibacterial activity , Computational modeling , Electrospinning , Essential oil , Modified cyclodextrins , Computation theory , Cyclodextrins , Electrospinning , Escherichia coli , Essential oils , Flavor compounds , Monoterpenes , Nanofibers , Oils and fats , Polymers , Spinning (fibers) , Anti-bacterial activity , Antibacterial properties , Computational model , Inclusion complex , Modified cyclodextrins , Polymeric matrices , Prolonged release , Water solubilities , Dissolution , Antiinfective agent , Cyclodextrin , Cyclohexene derivative , Drug carrier , Essential oil , Limonene , Nanofiber , Terpene , Chemistry , Drug effects , Drug release , Drug stability , Escherichia coli , Molecular computer , Nuclear magnetic resonance spectroscopy , Particle size , Scanning electron microscopy , Solubility , Staphylococcus aureus , Thermogravimetry , X ray crystallography , Anti-Bacterial Agents , Computers, Molecular , Crystallography, X-Ray , Cyclodextrins , Cyclohexenes , Drug Carriers , Drug Liberation , Drug Stability , Escherichia coli , Magnetic Resonance Spectroscopy , Microscopy, Electron, Scanning , Nanofibers , Oils, Volatile , Particle Size , Solubility , Staphylococcus aureus , Terpenes , Thermogravimetry

Citation

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http://hdl.handle.net/11693/36745

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https://doi.org/10.1021/acs.jafc.6b02632

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Institute of Materials Science and Nanotechnology (UNAM)
Nanotechnology Research Center (NANOTAM)