Antibacterial properties and osteoblast interactions of microfluidically synthesized chitosan – SPION composite nanoparticles

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buir.contributor.authorŞahinoğlu, O. Berkay
buir.contributor.authorAygun, Elif
buir.contributor.authorAlyuz , Beril
buir.contributor.authorSaritas, Emine Ulku
buir.contributor.authorErdem , E. Yegan
buir.contributor.orcidŞahinoğlu, O. Berkay|0000-0002-0984-9882
buir.contributor.orcidAygun, Elif|0000-0003-2934-6948
buir.contributor.orcidAlyuz, Beril| 0000-0001-9172-1505
buir.contributor.orcidSaritas, Emine Ulku| 0000-0001-8551-1077
buir.contributor.orcidErdem, E. Yegan| 0000-0001-9852-2293
dc.citation.epage1677en_US
dc.citation.issueNumber11
dc.citation.spage1662
dc.citation.volumeNumber111
dc.contributor.authorKafali, M.
dc.contributor.authorŞahinoğlu, O. Berkay
dc.contributor.authorTufan, Y.
dc.contributor.authorOrsel, Z. C.
dc.contributor.authorAygun, Elif
dc.contributor.authorAlyuz, Beril
dc.contributor.authorSaritas, Emine Ulku
dc.contributor.authorErdem, E. Yegan
dc.contributor.authorErcan, B.
dc.date.accessioned2024-03-07T17:40:54Z
dc.date.available2024-03-07T17:40:54Z
dc.date.issued2023-05-26
dc.departmentDepartment of Mechanical Engineering
dc.departmentDepartment of Electrical and Electronics Engineering
dc.departmentNational Magnetic Resonance Research Center (UMRAM)
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)
dc.description.abstractIn this research, a multi-step microfluidic reactor was used to fabricate chitosan – superparamagnetic iron oxide composite nanoparticles (Ch – SPIONs), where composite formation using chitosan was aimed to provide antibacterial property and nanoparticle stability for magnetic resonance imaging (MRI). Monodispersed Ch – SPIONs had an average particle size of 8.8 ± 1.2 nm with a magnetization value of 32.0 emu/g. Ch – SPIONs could be used as an MRI contrast agent by shortening T2 relaxation parameter of the surrounding environment, as measured on a 3 T MRI scanner. In addition, Ch – SPIONs with concentrations less than 1 g/L promoted bone cell (osteoblast) viability up to 7 days of culture in vitro in the presence of 0.4 T external static magnetic field. These nanoparticles were also tested against Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa), which are dangerous pathogens that cause infection in tissues and biomedical devices. Upon interaction of Ch – SPIONs with S. aureus and P. aeruginosa at 0.01 g/L concentration, nearly a 2-fold reduction in the number of colonies was observed for both bacteria strains at 48 h of culture. Results cumulatively showed that Ch – SPIONs were potential candidates as a cytocompatible and antibacterial agent that can be targeted to biofilm and imaged using an MRI.
dc.identifier.doi10.1002/jbm.a.37575
dc.identifier.eissn1552-4965
dc.identifier.issn1549-3296
dc.identifier.urihttps://hdl.handle.net/11693/114397
dc.language.isoen
dc.publisherWiley Periodicals LLC
dc.relation.isversionofhttps://doi.org/10.1002/jbm.a.37575
dc.rights.licenseCC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.source.titleJournal of Biomedical Materials Research Part A
dc.subjectAntibacterial
dc.subjectMagnetic field
dc.subjectMicrofluidics
dc.subjectOsteoblast
dc.subjectSPION
dc.titleAntibacterial properties and osteoblast interactions of microfluidically synthesized chitosan – SPION composite nanoparticles
dc.typeArticle

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Department of Mechanical Engineering
Department of Electrical and Electronics Engineering
Institute of Materials Science and Nanotechnology (UNAM)
National Magnetic Resonance Research Center (UMRAM)