Surface-modified bacterial nanofibrillar PHB scaffolds for bladder tissue repair

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dc.citation.epage82en_US
dc.citation.issueNumber1en_US
dc.citation.spage74en_US
dc.citation.volumeNumber44en_US
dc.contributor.authorKarahaliloǧlu, Z.en_US
dc.contributor.authorDemirbilek, M.en_US
dc.contributor.authorŞam, M.en_US
dc.contributor.authorSaǧlam, N.en_US
dc.contributor.authorMizrak, A. K.en_US
dc.contributor.authorDenkbaş, E. B.en_US
dc.date.accessioned2018-04-12T10:44:49Z
dc.date.available2018-04-12T10:44:49Z
dc.date.issued2016en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractThe aim of the study is in vitro investigation of the feasibility of surface-modified bacterial nanofibrous poly [(R)-3-hydroxybutyrate] (PHB) graft for bladder reconstruction. In this study, the surface of electrospun bacterial PHB was modified with PEG- or EDA via radio frequency glow discharge method. After plasma modification, contact angle of EDA-modified PHB scaffolds decreased from 110 � 1.50 to 23 � 0.5 degree. Interestingly, less calcium oxalate stone deposition was observed on modified PHB scaffolds compared to that of non-modified group. Results of this study show that surface-modified scaffolds not only inhibited calcium oxalate growth but also enhanced the uroepithelial cell viability and proliferation.en_US
dc.description.provenanceMade available in DSpace on 2018-04-12T10:44:49Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2016en
dc.identifier.doi10.3109/21691401.2014.913053en_US
dc.identifier.eissn2169-141Xen_US
dc.identifier.issn2169-1401
dc.identifier.urihttp://hdl.handle.net/11693/36575
dc.language.isoEnglishen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.isversionofhttp://dx.doi.org/10.3109/21691401.2014.913053en_US
dc.source.titleArtificial Cells, Nanomedicine and Biotechnologyen_US
dc.subjectBladder reconstructionen_US
dc.subjectCalcium oxalate stonesen_US
dc.subjectNanotextureen_US
dc.subjectPoly [(R)-3-hydroxybutyrate] (PHB)en_US
dc.subjectTissue engineeringen_US
dc.subjectCalciumen_US
dc.subjectGlow dischargesen_US
dc.subjectOxalic aciden_US
dc.subjectTissueen_US
dc.subjectTissue engineeringen_US
dc.subjectBladder reconstructionen_US
dc.subjectCalcium oxalatesen_US
dc.subjectNano-textureen_US
dc.subjectPlasma modificationsen_US
dc.subjectPoly[-3-hydroxybutyrate]en_US
dc.subjectRadio frequency glow dischargeen_US
dc.subjectSurface-modifieden_US
dc.subjectUroepithelial cellsen_US
dc.subjectScaffolds (biology)en_US
dc.subject3 hydroxybutyric aciden_US
dc.subjectCalciumen_US
dc.subjectCalcium oxalateen_US
dc.subjectMolecular scaffolden_US
dc.subjectPoly [(r) 3 hydroxybutyrate]en_US
dc.subjectUnclassified drugen_US
dc.subjectBiomaterialen_US
dc.subjectEthylenediamineen_US
dc.subjectEthylenediamine derivativeen_US
dc.subjectHydroxybutyric aciden_US
dc.subjectMacrogol derivativeen_US
dc.subjectAnimal cellen_US
dc.subjectArticleen_US
dc.subjectCalcium oxalate stoneen_US
dc.subjectCell proliferationen_US
dc.subjectCell viabilityen_US
dc.subjectChemical compositionen_US
dc.subjectContact angleen_US
dc.subjectCrystallizationen_US
dc.subjectElectrospinningen_US
dc.subjectFrequencyen_US
dc.subjectIn vitro studyen_US
dc.subjectNonhumanen_US
dc.subjectSurface propertyen_US
dc.subjectTissue repairen_US
dc.subjectAnimalen_US
dc.subjectBladderen_US
dc.subjectCell lineen_US
dc.subjectCell survivalen_US
dc.subjectChemistryen_US
dc.subjectCupriavidus necatoren_US
dc.subjectDrug effectsen_US
dc.subjectEpithelium cellen_US
dc.subjectIsolation and purificationen_US
dc.subjectMetabolismen_US
dc.subjectMouseen_US
dc.subjectNephrolithiasisen_US
dc.subjectPathologyen_US
dc.subjectPolymerizationen_US
dc.subjectRegenerationen_US
dc.subjectTissue engineeringen_US
dc.subjectAnimalsen_US
dc.subjectBiocompatible materialsen_US
dc.subjectCalcium oxalateen_US
dc.subjectCell lineen_US
dc.subjectCell proliferationen_US
dc.subjectCell survivalen_US
dc.subjectCupriavidus necatoren_US
dc.subjectEpithelial cellsen_US
dc.subjectEthylenediaminesen_US
dc.subjectHydroxybutyratesen_US
dc.subjectKidney calculien_US
dc.subjectMiceen_US
dc.subjectPolyethylene glycolsen_US
dc.subjectPolymerizationen_US
dc.subjectRegenerationen_US
dc.subjectTissue engineeringen_US
dc.subjectUrinary bladderen_US
dc.titleSurface-modified bacterial nanofibrillar PHB scaffolds for bladder tissue repairen_US
dc.typeArticleen_US

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