Poly(vinyl amine) microparticles derived from N-Vinylformamide and their versatile use

Date
2021-09-03
Advisor
Instructor
Source Title
Polymer Bulletin
Print ISSN
01700839
Electronic ISSN
Publisher
Springer
Volume
79
Issue
9
Pages
7729 - 7751
Language
English
Type
Article
Journal Title
Journal ISSN
Volume Title
Abstract

Cationic polymers with primary amine groups that can easily be functionalized or coupled with substrates by complexation or hydrogen bonding are especially advantageous in preparing particles for biomedical applications. Poly(vinyl amine) (PVAm) is a cationic polyelectrolyte containing the highest number of primary amine groups among any other polymers. Here, we introduce a general method in synthesizing PVAm microparticles via a surfactant-free water-in-oil emulsion technique using cyclohexane as the oil phase and aqueous PVAm solution as the dispersed phase. PVAm particles were prepared to employ two different bifunctional chemical crosslinkers, divinyl sulfone (DVS) and poly(ethylene glycol) diglycidyl ether (PEGGE). The prepared particles were further treated with HCl to protonate the amine groups of PVAm within particles. The effect of crosslinker types and pH on the hydrolytic degradation of PVAm particles were also investigated at three different solution pHs, 5.4, 7.4, and 9, to simulate the skin, blood, and intestinal pH environments, respectively. The blood compatibility of the PVAm particles was evaluated by in vitro hemolysis and blood clotting assays. Furthermore, antifungal and antibacterial efficacy of PVAm-based particles and their protonated forms were tested against C. albicans yeast and E. coli, S. aureus, B. subtilis, and P. aeruginosa bacterial strains. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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Other identifiers
Book Title
Keywords
Antibacterial/antifungal material, Blood compatible, Poly(vinyl amine), Polymeric microparticles
Citation
Published Version (Please cite this version)