Near-IR absorbing BODIPY derivatives as glutathione-activated photosensitizers for selective photodynamic action

Simple item page
dc.citation.epage16092en_US
dc.citation.issueNumber49en_US
dc.citation.spage16088en_US
dc.citation.volumeNumber20en_US
dc.contributor.authorTuran, I. S.en_US
dc.contributor.authorCakmak, F. P.en_US
dc.contributor.authorYildirim, D. C.en_US
dc.contributor.authorCetin Atalay, R.en_US
dc.contributor.authorAkkaya, E. U.en_US
dc.date.accessioned2016-02-08T10:58:54Z
dc.date.available2016-02-08T10:58:54Z
dc.date.issued2014en_US
dc.departmentDepartment of Chemistryen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractEnhanced spatiotemporal selectivity in photonic sensitization of dissolved molecular oxygen is an important target for improving the potential and the practical applications of photodynamic therapy. Considering the high intracellular glutathione concentrations within cancer cells, a series of BODIPY-based sensitizers that can generate cytotoxic singlet oxygen only after glutathione-mediated cleavage of the electron-sink module were designed and synthesized. Cell culture studies not only validate our design, but also suggest an additional role for the relatively hydrophobic quencher module in the internalization of the photosensitizer.en_US
dc.identifier.doi10.1002/chem.201405450en_US
dc.identifier.eissn1521-3765
dc.identifier.issn0947-6539
dc.identifier.urihttp://hdl.handle.net/11693/26369
dc.language.isoEnglishen_US
dc.publisherWiley-VCH Verlagen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/chem.201405450en_US
dc.source.titleChemistry: A European Journalen_US
dc.subjectBODIPY dyesen_US
dc.subjectPhotochemistryen_US
dc.subjectPhotodynamic actionen_US
dc.subjectPhotosensitizersen_US
dc.subjectSinglet oxygenen_US
dc.subjectCell cultureen_US
dc.subjectDissolved oxygenen_US
dc.subjectMolecular oxygenen_US
dc.subjectPeptidesen_US
dc.subjectPhotochemical reactionsen_US
dc.subjectPhotodynamic therapyen_US
dc.subjectBodipy dyesen_US
dc.subjectCancer cellsen_US
dc.subjectCytotoxicen_US
dc.subjectGlutathione concentrationen_US
dc.subjectGlutathionesen_US
dc.subjectNear-IRen_US
dc.subjectPhotodynamic actionen_US
dc.subjectSinglet oxygenen_US
dc.subjectPhotosensitizersen_US
dc.titleNear-IR absorbing BODIPY derivatives as glutathione-activated photosensitizers for selective photodynamic actionen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Near-IR absorbing BODIPY derivatives as glutathione-activated photosensitizers for selective photodynamic action.pdf
Size:
1.12 MB
Format:
Adobe Portable Document Format
Description:
Full printable version
Download
Collections
Department of Chemistry
Institute of Materials Science and Nanotechnology (UNAM)