Near-IR absorbing BODIPY derivatives as glutathione-activated photosensitizers for selective photodynamic action
Date
2014
Authors
Turan, I. S.
Cakmak, F. P.
Yildirim, D. C.
Cetin Atalay, R.
Akkaya, E. U.
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Abstract
Enhanced spatiotemporal selectivity in photonic sensitization of dissolved molecular oxygen is an important target for improving the potential and the practical applications of photodynamic therapy. Considering the high intracellular glutathione concentrations within cancer cells, a series of BODIPY-based sensitizers that can generate cytotoxic singlet oxygen only after glutathione-mediated cleavage of the electron-sink module were designed and synthesized. Cell culture studies not only validate our design, but also suggest an additional role for the relatively hydrophobic quencher module in the internalization of the photosensitizer.
Source Title
Chemistry: A European Journal
Publisher
Wiley-VCH Verlag
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Keywords
BODIPY dyes, Photochemistry, Photodynamic action, Photosensitizers, Singlet oxygen, Cell culture, Dissolved oxygen, Molecular oxygen, Peptides, Photochemical reactions, Photodynamic therapy, Bodipy dyes, Cancer cells, Cytotoxic, Glutathione concentration, Glutathiones, Near-IR, Photodynamic action, Singlet oxygen, Photosensitizers
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Language
English