Bio-inspired magnetic beads for isolation of sperm from heterogenous samples ın forensic applications

Simple item page
buir.contributor.authorİnci, Fatih
dc.citation.epage102451-8en_US
dc.citation.spage102451-1en_US
dc.citation.volumeNumber52en_US
dc.contributor.authorİnci, Fatih
dc.contributor.authorKaraaslan, M. G.
dc.contributor.authorGupta, R.
dc.contributor.authorAvadhani, A.
dc.contributor.authorÖğüt, M. G.
dc.contributor.authorAtila, E. E.
dc.contributor.authorDuncan, G.
dc.contributor.authorKlevan, L.
dc.contributor.authorDemirci, U.
dc.date.accessioned2022-02-11T08:45:03Z
dc.date.available2022-02-11T08:45:03Z
dc.date.issued2021-05
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractRapid and efficient processing of sexual assault evidence will accelerate forensic investigation and decrease casework backlogs. The standardized protocols currently used in forensic laboratories require the continued innovation to handle the increasing number and complexity of samples being submitted to forensic labs. Here, we present a new technique leveraging the integration of a bio-inspired oligosaccharide (i.e., Sialyl‐LewisX) with magnetic beads that provides a rapid, inexpensive, and easy-to-use strategy that can potentially be adapted with current differential extraction practice in forensics labs. This platform (i) selectively captures sperm; (ii) is sensitive within the forensic cut-off; (iii) provides a cost effective solution that can be automated with existing laboratory platforms; and (iv) handles small volumes of sample (∼200 μL). This strategy can rapidly isolate sperm within 25 minutes of total processing that will prepare the extracted sample for downstream forensic analysis and ultimately help accelerate forensic investigation and reduce casework backlogs.en_US
dc.description.provenanceSubmitted by Samet Emre (samet.emre@bilkent.edu.tr) on 2022-02-11T08:45:03Z No. of bitstreams: 1 Bio-inspired_magnetic_beads_for_isolation_of_sperm_from_heterogenous_samples_ın_forensic_applications.pdf: 3355723 bytes, checksum: 41e6897a6f590ee85b27fa7ce54b21f0 (MD5)en
dc.description.provenanceMade available in DSpace on 2022-02-11T08:45:03Z (GMT). No. of bitstreams: 1 Bio-inspired_magnetic_beads_for_isolation_of_sperm_from_heterogenous_samples_ın_forensic_applications.pdf: 3355723 bytes, checksum: 41e6897a6f590ee85b27fa7ce54b21f0 (MD5) Previous issue date: 2021-05en
dc.embargo.release2023-05-31
dc.identifier.doi10.1016/j.fsigen.2020.102451en_US
dc.identifier.issn1872-4973
dc.identifier.urihttp://hdl.handle.net/11693/77271
dc.language.isoEnglishen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofhttps://doi.org/10.1016/j.fsigen.2020.102451en_US
dc.source.titleForensic Science International: Geneticsen_US
dc.subjectSialyl LewisXen_US
dc.subjectMagnetic beadsen_US
dc.subjectBio-inspired materialen_US
dc.subjectCell separationen_US
dc.subjectForensicsen_US
dc.titleBio-inspired magnetic beads for isolation of sperm from heterogenous samples ın forensic applicationsen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Bio-inspired_magnetic_beads_for_isolation_of_sperm_from_heterogenous_samples_ın_forensic_applications.pdf
Size:
3.2 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.69 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Institute of Materials Science and Nanotechnology (UNAM)