Biocompatibility studies on lanthanum oxide nanoparticles

dc.citation.epage1044en_US
dc.citation.issueNumber4en_US
dc.citation.spage1037en_US
dc.citation.volumeNumber4en_US
dc.contributor.authorBrabu, B.en_US
dc.contributor.authorHaribabu, S.en_US
dc.contributor.authorRevathy, M.en_US
dc.contributor.authorAnitha, S.en_US
dc.contributor.authorThangapandiyan, M.en_US
dc.contributor.authorNavaneethakrishnan, K. R.en_US
dc.contributor.authorGopalakrishnan, C.en_US
dc.contributor.authorMurugan, S. S.en_US
dc.contributor.authorKumaravel, T. S.en_US
dc.date.accessioned2016-02-08T09:47:51Z
dc.date.available2016-02-08T09:47:51Z
dc.date.issued2015en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractLanthanum oxide nanoparticles (LONP), a rare earth metal oxide, have unique properties that make them a suitable candidate for several biomedical applications. We investigated certain key in vitro and in vivo biocompatibility endpoints on LONP. LONP were cytotoxic in in vitro assays and predominantly exerted their action via release of reactive oxygen species. These nanoparticles were neither irritants nor sensitizers in a rabbit model. LONP extracts did not exert any acute systemic toxicity effects in mice. On the other hand LONP exerted toxicity to the liver following oral administration, suggesting that these particles are absorbed from the gastrointestinal (GI) tract and deposited in the hepatobiliary system. LONP did not induce any mutation in the Ames test both in the presence or absence of S-9. These observations provide a base line biocompatibility and toxicity data on LONP. The current findings will also be useful in defining standards for nanoparticle containing devices. © The Royal Society of Chemistry.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T09:47:51Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2015en
dc.identifier.doi10.1039/c4tx00198ben_US
dc.identifier.issn2045-452X
dc.identifier.urihttp://hdl.handle.net/11693/21547
dc.language.isoEnglishen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.isversionofhttps://doi.org/10.1039/c4tx00198ben_US
dc.source.titleToxicology Researchen_US
dc.subjectIrritant agenten_US
dc.subjectLanthanum oxideen_US
dc.subjectNanoparticleen_US
dc.subjectReactive oxygen metaboliteen_US
dc.subjectS 9en_US
dc.subjectAcute toxicityen_US
dc.subjectAmes testen_US
dc.subjectAnimal cellen_US
dc.subjectAnimal experimenten_US
dc.subjectAnimal modelen_US
dc.subjectApoptosisen_US
dc.subjectArticleen_US
dc.subjectBiocompatibilityen_US
dc.subjectConcentration (parameters)en_US
dc.subjectControlled studyen_US
dc.subjectGastrointestinal absorptionen_US
dc.subjectHepatobiliary systemen_US
dc.subjectHydrodynamicsen_US
dc.subjectIn vitro studyen_US
dc.subjectIn vivo studyen_US
dc.subjectLipid peroxidationen_US
dc.subjectLiver toxicityen_US
dc.subjectMouseen_US
dc.subjectMutational analysisen_US
dc.subjectNonhumanen_US
dc.subjectPriority journalen_US
dc.subjectRabbit modelen_US
dc.subjectToxicity testingen_US
dc.subjectZeta potentialen_US
dc.subjectMusen_US
dc.subjectOryctolagus cuniculusen_US
dc.titleBiocompatibility studies on lanthanum oxide nanoparticlesen_US
dc.typeArticleen_US

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