Biocompatibility studies on lanthanum oxide nanoparticles

Date
2015
Authors
Brabu, B.
Haribabu, S.
Revathy, M.
Anitha, S.
Thangapandiyan, M.
Navaneethakrishnan, K. R.
Gopalakrishnan, C.
Murugan, S. S.
Kumaravel, T. S.
Advisor
Instructor
Source Title
Toxicology Research
Print ISSN
2045-452X
Electronic ISSN
Publisher
Royal Society of Chemistry
Volume
4
Issue
4
Pages
1037 - 1044
Language
English
Type
Article
Journal Title
Journal ISSN
Volume Title
Abstract

Lanthanum oxide nanoparticles (LONP), a rare earth metal oxide, have unique properties that make them a suitable candidate for several biomedical applications. We investigated certain key in vitro and in vivo biocompatibility endpoints on LONP. LONP were cytotoxic in in vitro assays and predominantly exerted their action via release of reactive oxygen species. These nanoparticles were neither irritants nor sensitizers in a rabbit model. LONP extracts did not exert any acute systemic toxicity effects in mice. On the other hand LONP exerted toxicity to the liver following oral administration, suggesting that these particles are absorbed from the gastrointestinal (GI) tract and deposited in the hepatobiliary system. LONP did not induce any mutation in the Ames test both in the presence or absence of S-9. These observations provide a base line biocompatibility and toxicity data on LONP. The current findings will also be useful in defining standards for nanoparticle containing devices. © The Royal Society of Chemistry.

Course
Other identifiers
Book Title
Keywords
Irritant agent, Lanthanum oxide, Nanoparticle, Reactive oxygen metabolite, S 9, Acute toxicity, Ames test, Animal cell, Animal experiment, Animal model, Apoptosis, Article, Biocompatibility, Concentration (parameters), Controlled study, Gastrointestinal absorption, Hepatobiliary system, Hydrodynamics, In vitro study, In vivo study, Lipid peroxidation, Liver toxicity, Mouse, Mutational analysis, Nonhuman, Priority journal, Rabbit model, Toxicity testing, Zeta potential, Mus, Oryctolagus cuniculus
Citation
Published Version (Please cite this version)