Biotin functionalized self‐assembled peptide nanofiber as an adjuvant for immunomodulatory response

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buir.contributor.authorDemircan, Muhammed Burak
buir.contributor.authorTohumeken, Sehmus
buir.contributor.authorGündüz, Nuray
buir.contributor.authorKhalily, Mohammad Aref
buir.contributor.authorTekinay, Ayşe B.
dc.citation.issueNumber12en_US
dc.citation.spage2000100en_US
dc.citation.volumeNumber15en_US
dc.contributor.authorDemircan, Muhammed Burak
dc.contributor.authorTohumeken, Sehmus
dc.contributor.authorGündüz, Nuray
dc.contributor.authorKhalily, Mohammad Aref
dc.contributor.authorTekinay, T.
dc.contributor.authorGüler, M. O.
dc.contributor.authorTekinay, Ayşe B.
dc.date.accessioned2021-02-28T20:29:28Z
dc.date.available2021-02-28T20:29:28Z
dc.date.issued2020-12
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentInterdisciplinary Program in Neuroscience (NEUROSCIENCE)en_US
dc.description.abstractBiotinylated peptide amphiphile (Biotin‐PA) nanofibers, are designed as a noncovalent binding location for antigens, which are adjuvants to enhance, accelerate, and prolong the immune response triggered by antigens. Presenting antigens on synthetic Biotin‐PA nanofibers generated a higher immune response than the free antigens delivered with a cytosine‐phosphate‐guanine oligodeoxynucleotides (CpG ODN) (TLR9 agonist) adjuvant. Antigen attached Biotin‐PA nanofibers trigger splenocytes to produce high levels of cytokines (IFN‐γ, IL‐12, TNF‐α, and IL‐6) and to exhibit a superior cross‐presentation of the antigen. Both Biotin‐PA nanofibers and CpG ODN induce a Th‐1‐biased IgG subclass response; however, delivering the antigen with Biotin‐PA nanofibers induce significantly greater production of total IgG and subclasses of IgG compared to delivering the antigen with CpG ODN. Contrary to CpG ODN, Biotin‐PA nanofibers also enhance antigen‐specific splenocyte proliferation and increase the proportion of the antigen‐specific CD8(+) T cells. Given their biodegradability and biocompatibility, Biotin‐PA nanofibers have a significant potential in immunoengineering applications as a biomaterial for the delivery of a diverse set of antigens derived from intracellular pathogens, emerging viral diseases such as COVID‐19, or cancer cells to induce humoral and cellular immune responses against the antigens.en_US
dc.embargo.release2021-12-07
dc.identifier.doi10.1002/biot.202000100en_US
dc.identifier.issn1860-6768
dc.identifier.urihttp://hdl.handle.net/11693/75650
dc.language.isoEnglishen_US
dc.publisherWiley-VCH Verlagen_US
dc.relation.isversionofhttps://dx.doi.org/10.1002/biot.202000100en_US
dc.source.titleBiotechnology Journalen_US
dc.subjectAdjuvanten_US
dc.subjectPeptide nanofiberen_US
dc.subjectSelf‐assemblyen_US
dc.subjectVaccineen_US
dc.subjectVirus‐like particlesen_US
dc.titleBiotin functionalized self‐assembled peptide nanofiber as an adjuvant for immunomodulatory responseen_US
dc.typeArticleen_US

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Institute of Materials Science and Nanotechnology (UNAM)