Macroporous Surgical Mesh from a Natural Cocoon Composite

Date
2022-04-25
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Source Title
ACS Sustainable Chemistry and Engineering
Print ISSN
2168-0485
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Volume
10
Issue
18
Pages
5728 - 5738
Language
English
Type
Article
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Abstract

Recently, traditional polymer-based surgical meshes have drawn unwanted attention as a result of host tissue complications arising from infection, biocompatibility, and mechanical compatibility. Seeking an alternative solution, we present a hierarchically structured nanofibrous surgical mesh derived from the naturally woven cocoon of the Japanese giant silkworm, termed MothMesh. We report that it displays nontoxicity, biocompatibility, suitable mechanical properties, and porosity while showing no adverse effect in animal trials and even appears to enhance cell proliferation. Hence, we assert that the use of this natural material may provide an effective and improved alternative to existing synthetic meshes

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Keywords
Sustainable material, Fibroin, Sericin, Biocompatibility, Surgical mesh, Tissue engineering
Citation
Published Version (Please cite this version)