A smartphone based surface plasmon resonance imaging (SPRi) platform for on-site biodetection

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Date

2017

Authors

Guner, H.
Ozgur, E.
Kokturk, G.
Celik, M.
Esen, E.
Topal, A. E.
Ayas, S.
Uludag, Y.
Elbuken, C.
Dana, A.

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Abstract

We demonstrate a surface plasmon resonance imaging platform integrated with a smartphone to be used in the field with high-throughput biodetection. Inexpensive and disposable SPR substrates are produced by metal coating of commercial Blu-ray discs. A compact imaging apparatus is fabricated using a 3D printer which allows taking SPR measurements from more than 20.000 individual pixels. Real-time bulk refractive index change measurements yield noise equivalent refractive index changes as low as 4.12 × 10−5 RIU which is comparable with the detection performance of commercial instruments. As a demonstration of a biological assay, we have shown capture of mouse IgG antibodies by immobilized layer of rabbit anti-mouse (RAM) IgG antibody with nanomolar level limit of detection. Our approach in miniaturization of SPR biosensing in a cost-effective manner could enable realization of portable SPR measurement systems and kits for point-of-care applications.

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Sensors and Actuators, B: Chemical

Publisher

Elsevier

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Published Version (Please cite this version)

Language

English