In vitro biocompatibility of plasma-aided surface-modified 316L stainless steel for intracoronary stents

Date

2010

Authors

Bayram, C.
Mizrak, A.K.
Aktürk, S.
Kurşaklioǧlu H.
Iyisoy, A.
Ifran, A.
Denkbaş, E.B.

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Source Title

Biomedical Materials

Print ISSN

17486041

Electronic ISSN

Publisher

Institute of Physics Publishing

Volume

5

Issue

5

Pages

Language

English

Type

Article

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Abstract

316L-type stainless steel is a raw material mostly used for manufacturing metallic coronary stents. The purpose of this study was to examine the chemical, wettability, cytotoxic and haemocompatibility properties of 316L stainless steel stents which were modified by plasma polymerization. Six different polymeric compounds, polyethylene glycol, 2-hydroxyethyl methacrylate, ethylenediamine, acrylic acid, hexamethyldisilane and hexamethyldisiloxane, were used in a radio frequency glow discharge plasma polymerization system. As a model antiproliferative drug, mitomycin-C was chosen for covalent coupling onto the stent surface. Modified SS 316L stents were characterized by water contact angle measurements (goniometer) and x-ray photoelectron spectroscopy. C1s binding energies showed a good correlation with the literature. Haemocompatibility tests of coated SS 316L stents showed significant latency (t-test, p < 0.05) with respect to SS 316L and control groups in each test. © 2010 IOP Publishing Ltd.

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Keywords

Angle measurement, Binding energy, Biocompatibility, Carboxylic acids, Contact angle, Corrosion resistant alloys, Glow discharges, Organic acids, Plasma polymerization, Polyethylene glycols, Polyethylene oxides, Polyethylenes, Polymers, X ray photoelectron spectroscopy, 2-hydroxyethyl methacrylate, 316 L stainless steel, Acrylic acids, Anti-proliferative, Control groups, Coronary stents, Covalent couplings, Cytotoxic, Ethylene diamine, Good correlations, Haemocompatibility, Hexamethyl disiloxane, Hexamethyldisilanes, In-vitro, Intra-coronary stents, Mitomycin C, Polymeric compounds, Polymerization systems, Radio frequency glow discharge, Surface-modified, Water contact angle measurement, Stainless steel, 2 hydroxyethyl methacrylate, acrylic acid, ethylenediamine, hexamethyldisilane, hexamethyldisiloxane, macrogol, mitomycin C, silane derivative, stainless steel, unclassified drug, 2 hydroxyethyl methacrylate, antineoplastic antibiotic, biomaterial, macrogol derivative, methacrylic acid derivative, mitomycin, polymer, animal cell, article, biocompatibility, contact angle, controlled study, coronary stent, cytotoxicity, human, mouse, nonhuman, physical chemistry, plasma, polymerization, surface property, wettability, blood, blood clotting test, body fluid, chemistry, comparative study, stent, toxicity testing, X ray photoelectron spectroscopy, Antibiotics, Antineoplastic, Blood, Blood Coagulation Tests, Body Fluids, Coated Materials, Biocompatible, Humans, Methacrylates, Mitomycin, Photoelectron Spectroscopy, Polyethylene Glycols, Polymers, Stainless Steel, Stents, Surface Properties, Toxicity Tests, Wettability

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http://hdl.handle.net/11693/22464

Published Version (Please cite this version)

http://dx.doi.org/10.1088/1748-6041/5/5/055007

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Scholarly Publications - UNAM