Spiral microfluidics device for continuous flow PCR

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dc.citation.volumeNumber2en_US
dc.contributor.authorSalemmilani, Rezaen_US
dc.contributor.authorÇetin, Barbarosen_US
dc.coverage.spatialMinneapolis, MN, USAen_US
dc.date.accessioned2016-02-08T12:05:45Z
dc.date.available2016-02-08T12:05:45Z
dc.date.issued2013en_US
dc.departmentDepartment of Mechanical Engineeringen_US
dc.descriptionDate of Conference: July 14–19, 2013en_US
dc.descriptionConference name: Proceedings of the ASME 2013 Heat Transfer Summer Conference HT2013en_US
dc.description.abstractPolymerase-chain-Reaction (PCR) is a thermal cycling (repeated heating and cooling of PCR solution) process for DNA amplification. PCR is the key ingredient in many biomedical applications. One key feature for the success of the PCR is to control the temperature of the solution precisely at the desired temperature levels required for the PCR in a cyclic manner. Microfluidics offers a great advantage over conventional techniques since minute amounts of PCR solution can be heated and cooled with a high rate in a controlled manner. In this study, a microfluidic platform has been proposed for continuous-flow PCR. The microfluidic device consists of a spiral channel on a glass wafer with integrated chromium microheaters. Sub-micron thick microheaters are deposited beneath the micro-channels to facilitate localized heating. The microfluidic device is modeled using COMSOL MultiphysicsR . The fabrication procedure of the device is also discussed and future research directions are addressed. With its compact design, the proposed system can easily be coupled with an integrated microfluidic device to be used in biomedical applications. Copyright © 2013 by ASME.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T12:05:45Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2013en
dc.identifier.doi10.1115/HT2013-17305en_US
dc.identifier.urihttp://hdl.handle.net/11693/27935
dc.language.isoEnglishen_US
dc.publisherASMEen_US
dc.relation.isversionofhttp://dx.doi.org/10.1115/HT2013-17305en_US
dc.source.titleProceedings of the ASME 2017 Summer Heat Transfer Conference (HT2017)en_US
dc.subjectBiomedical applicationsen_US
dc.subjectConventional techniquesen_US
dc.subjectFabrication procedureen_US
dc.subjectFuture research directionsen_US
dc.subjectIntegrated microfluidic devicesen_US
dc.subjectMicro-fluidic devicesen_US
dc.subjectMicrofluidic platformsen_US
dc.subjectMicrofluidics devicesen_US
dc.subjectFluidic devicesen_US
dc.subjectFuel cellsen_US
dc.subjectHeat transferen_US
dc.subjectHeating equipmenten_US
dc.subjectMass transferen_US
dc.subjectMedical applicationsen_US
dc.subjectMicroelectromechanical devicesen_US
dc.subjectMicrofluidicsen_US
dc.subjectSustainable developmenten_US
dc.subjectPolymerase chain reactionen_US
dc.titleSpiral microfluidics device for continuous flow PCRen_US
dc.typeConference Paperen_US

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