Encapsulation of antioxidant beta-carotene by cyclodextrin complex electrospun nanofibers: solubilization and stabilization of beta-carotene by cyclodextrins

Available
The embargo period has ended, and this item is now available.

Date

2023-04-29

Editor(s)

Advisor

Supervisor

Co-Advisor

Co-Supervisor

Instructor

BUIR Usage Stats
23
views
15
downloads

Citation Stats

Series

Abstract

Carotenoids act as effective antioxidant defense systems in humans as they scavenge molecular oxygen and peroxyl radicals. However, their poor water solubility and being susceptible to degradation driven by light and oxygen hinder their bioactivity, therefore, they should be stabilized by host matrices against oxidation. Here, β-carotene was encapsulated in electrospun cyclodextrin (CD) nanofibers to increase its water-solubility and photostability to enhance its antioxidant bioactivity. β-carotene/CD complex aqueous solutions were electrospun into nanofibers. The bead-free morphology of the β-carotene/CD nanofibers was confirmed by SEM. The formation of β-carotene/CD complexes was explored through computational modeling and experimentally by FTIR, XRD and solubility tests. The antioxidant activity of the fibers exposed to UV irradiation was demonstrated via a free radical scavenger assay, where β-carotene/CD nanofibers revealed protection against UV radiation. Overall, this work reports the water-borne electrospinning of antioxidant β-carotene/CD inclusion complex nanofibers, which stabilize the encapsulated β-carotene against UV-mediated oxidation.

Source Title

Food Chemistry

Publisher

Elsevier BV

Course

Other identifiers

Book Title

Degree Discipline

Degree Level

Degree Name

Citation

Published Version (Please cite this version)

Language

en