Microfluidics-integrated microwave sensors for single cells size discrimination

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buir.contributor.authorSeçme, Arda
buir.contributor.authorPisheh, Hadi Sedaghat
buir.contributor.authorUslu, H. Dilara
buir.contributor.authorAkbulut, Özge
buir.contributor.authorErdoğan, R. Tufan
buir.contributor.authorHanay, Mehmet Selim
dc.citation.epage3
dc.citation.spage1
dc.contributor.authorSeçme, Arda
dc.contributor.authorPisheh, Hadi Sedaghat
dc.contributor.authorUslu, H. Dilara
dc.contributor.authorAkbulut, Özge
dc.contributor.authorErdoğan, R. Tufan
dc.contributor.authorHanay, Mehmet Selim
dc.coverage.spatialToulouse, France
dc.date.accessioned2024-07-10T10:14:22Z
dc.date.available2024-07-10T10:14:22Z
dc.date.issued2021-04
dc.departmentDepartment of Mechanical Engineering
dc.departmentDepartment of Molecular Biology and Genetics
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)
dc.descriptionDate of Conference: 14-17 December 2020
dc.descriptionConference Name: Proceedings of the 2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)
dc.description.abstractThe size of a cell is one of the most fundamental biophysical parameters it possesses. Traditionally size measurements are done by using optical microscopy and quantitative phase imaging. However, a sensor with higher resolution, high throughput and lower cost is still needed. Here, a novel microfluidics-integrated microwave sensor is demonstrated to characterize single cells in real-time without labelling. Coplanar waveguide resonator is designed with a bowtie-shaped sensing electrodes separated by 50 μm. Cells are transported to sensing region by microfluidic channels and their sizes are measured simultaneously by the microwave sensors and optical microscopy. To enhance the microwave resolution, the microwave resonator is equipped with external heterodyne measurement circuitry detecting each and every cell passing through the sensing region. By comparing quantitative microscopic image analysis with frequency shifts, we show that microwave sensors can effectively measure cellular size. Our results indicate that microfluidics-integrated microwave sensors (MIMS) can be used for detecting.
dc.identifier.doi10.1109/IMBIoC47321.2020.9385048
dc.identifier.issn0149-645X
dc.identifier.urihttps://hdl.handle.net/11693/115349
dc.language.isoen
dc.publisherInstitute of Electrical and Electronics Engineers
dc.relation.isversionofhttps://dx.doi.org/10.1109/IMBIoC47321.2020.9385048
dc.relation.project2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC), Toulouse, France, 2020
dc.subjectcell size
dc.subjectMIMS
dc.subjectmicrowave resonators
dc.titleMicrofluidics-integrated microwave sensors for single cells size discrimination
dc.typeConference Paper

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Department of Mechanical Engineering
Department of Molecular Biology and Genetics
Institute of Materials Science and Nanotechnology (UNAM)