Increased frequency of extremely skewed X chromosome inactivation in juvenile idiopathic arthritis

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dc.citation.epage3412en_US
dc.citation.issueNumber11en_US
dc.citation.spage3410en_US
dc.citation.volumeNumber60en_US
dc.contributor.authorUz, E.en_US
dc.contributor.authorMustafa, C.en_US
dc.contributor.authorTopaloglu, R.en_US
dc.contributor.authorBilginer, Y.en_US
dc.contributor.authorDursun, A.en_US
dc.contributor.authorKasapcopur, O.en_US
dc.contributor.authorOzen, S.en_US
dc.contributor.authorBakkaloglu, A.en_US
dc.contributor.authorOzcelik, T.en_US
dc.date.accessioned2016-02-08T10:01:53Z
dc.date.available2016-02-08T10:01:53Z
dc.date.issued2009en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractObjective. Juvenile idiopathic arthritis (JIA) is a childhood rheumatic disease of unknown etiology. Two subgroups of JIA, i.e., oligoarticular and polyarticular, are thought to have an autoimmune component, and show a higher female:male ratio. Skewed X chromosome inactivation (XCI) has previously been shown to be associated with scleroderma and autoimmune thyroiditis, 2 autoimmune disorders occurring predominantly in females. This study was undertaken to extend the analysis to the pediatric age group and to determine the XCI profiles of patients with JIA.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T10:01:53Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2009en
dc.identifier.doi10.1002/art.24956en_US
dc.identifier.issn2326-5205
dc.identifier.urihttp://hdl.handle.net/11693/22574
dc.language.isoEnglishen_US
dc.publisherJohn Wiley & Sons, Inc.en_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/art.24956en_US
dc.source.titleArthritis and Rheumatismen_US
dc.subjectAndrogen receptoren_US
dc.subjectDNAen_US
dc.subjectImmunosuppressive agenten_US
dc.subjectMethotrexateen_US
dc.subjectNonsteroid antiinflammatory agenten_US
dc.subjectArticleen_US
dc.subjectBlood samplingen_US
dc.subjectControlled studyen_US
dc.subjectDNA polymorphismen_US
dc.subjectFemaleen_US
dc.subjectGene frequencyen_US
dc.subjectHumanen_US
dc.subjectJuvenile rheumatoid arthritisen_US
dc.subjectMajor clinical studyen_US
dc.subjectPriority journalen_US
dc.subjectX chromosome inactivationen_US
dc.subjectAdolescenten_US
dc.subjectArthritis, Juvenile Rheumatoiden_US
dc.subjectCase-Control Studiesen_US
dc.subjectChilden_US
dc.subjectChild, Preschoolen_US
dc.subjectChromosomes, Human, Xen_US
dc.subjectFemaleen_US
dc.subjectGenetic Predisposition to Diseaseen_US
dc.subjectGenotypeen_US
dc.subjectHeterozygoteen_US
dc.subjectHumansen_US
dc.subjectMutationen_US
dc.subjectReceptors, Androgenen_US
dc.subjectRisk Factorsen_US
dc.subjectX Chromosome Inactivationen_US
dc.titleIncreased frequency of extremely skewed X chromosome inactivation in juvenile idiopathic arthritisen_US
dc.typeArticleen_US

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