Increased frequency of extremely skewed X chromosome inactivation in juvenile idiopathic arthritis
Date
2009
Authors
Uz, E.
Mustafa, C.
Topaloglu, R.
Bilginer, Y.
Dursun, A.
Kasapcopur, O.
Ozen, S.
Bakkaloglu, A.
Ozcelik, T.
Advisor
Instructor
Source Title
Arthritis and Rheumatism
Print ISSN
2326-5205
Electronic ISSN
Publisher
John Wiley & Sons, Inc.
Volume
60
Issue
11
Pages
3410 - 3412
Language
English
Type
Article
Journal Title
Journal ISSN
Volume Title
Abstract
Objective. Juvenile idiopathic arthritis (JIA) is a childhood rheumatic disease of unknown etiology. Two subgroups of JIA, i.e., oligoarticular and polyarticular, are thought to have an autoimmune component, and show a higher female:male ratio. Skewed X chromosome inactivation (XCI) has previously been shown to be associated with scleroderma and autoimmune thyroiditis, 2 autoimmune disorders occurring predominantly in females. This study was undertaken to extend the analysis to the pediatric age group and to determine the XCI profiles of patients with JIA.
Course
Other identifiers
Book Title
Keywords
Androgen receptor, DNA, Immunosuppressive agent, Methotrexate, Nonsteroid antiinflammatory agent, Article, Blood sampling, Controlled study, DNA polymorphism, Female, Gene frequency, Human, Juvenile rheumatoid arthritis, Major clinical study, Priority journal, X chromosome inactivation, Adolescent, Arthritis, Juvenile Rheumatoid, Case-Control Studies, Child, Child, Preschool, Chromosomes, Human, X, Female, Genetic Predisposition to Disease, Genotype, Heterozygote, Humans, Mutation, Receptors, Androgen, Risk Factors, X Chromosome Inactivation