Increased frequency of extremely skewed X chromosome inactivation in juvenile idiopathic arthritis
Date
2009
Authors
Uz, E.
Mustafa, C.
Topaloglu, R.
Bilginer, Y.
Dursun, A.
Kasapcopur, O.
Ozen, S.
Bakkaloglu, A.
Ozcelik, T.
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Supervisor
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Instructor
Source Title
Arthritis and Rheumatism
Print ISSN
2326-5205
Electronic ISSN
Publisher
John Wiley & Sons, Inc.
Volume
60
Issue
11
Pages
3410 - 3412
Language
English
Type
Journal Title
Journal ISSN
Volume Title
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Abstract
Objective. Juvenile idiopathic arthritis (JIA) is a childhood rheumatic disease of unknown etiology. Two subgroups of JIA, i.e., oligoarticular and polyarticular, are thought to have an autoimmune component, and show a higher female:male ratio. Skewed X chromosome inactivation (XCI) has previously been shown to be associated with scleroderma and autoimmune thyroiditis, 2 autoimmune disorders occurring predominantly in females. This study was undertaken to extend the analysis to the pediatric age group and to determine the XCI profiles of patients with JIA.
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Keywords
Androgen receptor, DNA, Immunosuppressive agent, Methotrexate, Nonsteroid antiinflammatory agent, Article, Blood sampling, Controlled study, DNA polymorphism, Female, Gene frequency, Human, Juvenile rheumatoid arthritis, Major clinical study, Priority journal, X chromosome inactivation, Adolescent, Arthritis, Juvenile Rheumatoid, Case-Control Studies, Child, Child, Preschool, Chromosomes, Human, X, Female, Genetic Predisposition to Disease, Genotype, Heterozygote, Humans, Mutation, Receptors, Androgen, Risk Factors, X Chromosome Inactivation