Xenogenic neural stem cell-derived extracellular nanovesicles modulate human mesenchymal stem cell fate and reconstruct metabolomic structure

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buir.contributor.authorElbüken, Çaglar
buir.contributor.orcidElbüken, Çaglar|0000-0001-8359-6871
dc.citation.epage2101317- 15en_US
dc.citation.issueNumber6en_US
dc.citation.spage2101317- 1en_US
dc.citation.volumeNumber6en_US
dc.contributor.authorDerkus, B.
dc.contributor.authorIsik, M.
dc.contributor.authorEylem, C. C.
dc.contributor.authorErgin, İ.
dc.contributor.authorCamci, C. B.
dc.contributor.authorBilgin, S.
dc.contributor.authorElbüken, Çaglar
dc.contributor.authorArslan, Y. E.
dc.contributor.authorAkkulak, M.
dc.contributor.authorAdali, O.
dc.contributor.authorKiran, F.
dc.contributor.authorOkesola, B. O.
dc.contributor.authorNemutlu, E.
dc.contributor.authorEmregul, E.
dc.date.accessioned2023-02-27T07:53:15Z
dc.date.available2023-02-27T07:53:15Z
dc.date.issued2022-03-28
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractExtracellular nanovesicles, particularly exosomes, can deliver their diverse bioactive biomolecular content, including miRNAs, proteins, and lipids, thus providing a context for investigating the capability of exosomes to induce stem cells toward lineage-specific cells and tissue regeneration. In this study, it is demonstrated that rat subventricular zone neural stem cell-derived exosomes (rSVZ-NSCExo) can control neural-lineage specification of human mesenchymal stem cells (hMSCs). Microarray analysis shows that the miRNA content of rSVZ-NSCExo is a faithful representation of rSVZ tissue. Through immunocytochemistry, gene expression, and multi-omics analyses, the capability to use rSVZ-NSCExo to induce hMSCs into a neuroglial or neural stem cell phenotype and genotype in a temporal and dose-dependent manner via multiple signaling pathways is demonstrated. The current study presents a new and innovative strategy to modulate hMSCs fate by harnessing the molecular content of exosomes, thus suggesting future opportunities for rSVZ-NSCExo in nerve tissue regeneration.en_US
dc.identifier.doi10.1002/adbi.202101317en_US
dc.identifier.eissn2701-0198
dc.identifier.urihttp://hdl.handle.net/11693/111794
dc.language.isoEnglishen_US
dc.publisherWiley-VCH Verlag GmbH & Co. KGaAen_US
dc.relation.isversionofhttps://dx.doi.org/10.1002/adbi.202101317en_US
dc.source.titleAdvanced Biologyen_US
dc.titleXenogenic neural stem cell-derived extracellular nanovesicles modulate human mesenchymal stem cell fate and reconstruct metabolomic structureen_US
dc.typeArticleen_US

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