Synthesis of iron oxide core chitosan nanoparticles in a 3D printed microfluidic device

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buir.contributor.authorÇetin, Barbaros
buir.contributor.orcidÇetin, Barbaros|0000-0001-9824-4000
dc.citation.epage62 (10)en_US
dc.citation.spage62 (1)en_US
dc.citation.volumeNumber23en_US
dc.contributor.authorAşık, M.D.
dc.contributor.authorKaplan, M.
dc.contributor.authorÇetin, Barbaros
dc.contributor.authorSağlam, N.
dc.date.accessioned2022-02-09T11:30:26Z
dc.date.available2022-02-09T11:30:26Z
dc.date.issued2021-03-02
dc.departmentDepartment of Mechanical Engineeringen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractNanostructures are capable of major changes in our life. However, the game changing properties of experimental nanostructures mostly are not repeatable for the industry and it is not easy to produce the amount of nanoparticles necessary for the industrial world. Repeatable methods, which do not require highly trained personnel, for industrial-scale production should be developed to transfer the academic research to the use of people. Although there are various successful microfluidics devices that have been designed for microstructures synthesis, the synthesis of the nanostructures is not an enlightened area and there is a need for research to reach a better state. Especially, the development and design of microfluidics devices for biopolymeric nanoparticles are very important. The biopolymeric nanoparticles have uses in both nanotechnology and nanomedicine especially as theragnostic tools. In this study, a microfluidic device has been modeled, designed, and manufactured for especially iron oxide core chitosan nanoparticles. The microfluidics channels were manufactured by 3D printing. After nanoparticles synthesized by manufactured device, these particles were characterized, and their properties were examined. In addition to the flow rate, chemical concentrations, and pH, the structure of the microfluidics channel and hurdles have effects on the particle size and particle size distribution. Best results were obtained with 120-120ml/h flow rates and 0.06-0.03% concentrations at pH 4.5 for chitosan-tripolyphosphate couple. The nanoparticles that were produced in microchannels with hurdles under these conditions have a DLS measurement of 190±15 nm in diameter with 69% intensity. In conclusion, the 3D printed microfluidic channels are able to synthesize nanoparticles in a reproducible way with or without iron oxide core.en_US
dc.identifier.doi10.1007/s11051-021-05171-yen_US
dc.identifier.eissn1572-896X
dc.identifier.issn1388-0764
dc.identifier.urihttp://hdl.handle.net/11693/77169
dc.language.isoEnglishen_US
dc.publisherSpringeren_US
dc.relation.isversionofhttps://doi.org/10.1007/s11051-021-05171-yen_US
dc.source.titleJournal of Nanoparticle Researchen_US
dc.subjectMicrofluidicsen_US
dc.subjectIron oxide nanoparticlesen_US
dc.subjectChitosan nanoparticlesen_US
dc.subjectMicrofluidic nanoparticle synthesisen_US
dc.subjectNanofabricationen_US
dc.titleSynthesis of iron oxide core chitosan nanoparticles in a 3D printed microfluidic deviceen_US
dc.typeArticleen_US

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