Assessment of silicon, glass, FR4, PDMS and PMMA as a chip material for acoustic particle/cell manipulation in microfluidics

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buir.contributor.authorAçıkgöz, Hande N.
buir.contributor.authorŞahin, M. Akif
buir.contributor.authorÇetin, Barbaros
dc.citation.epage13en_US
dc.citation.spage1en_US
dc.citation.volumeNumber129en_US
dc.contributor.authorAçıkgöz, Hande N.
dc.contributor.authorKaraman, A.
dc.contributor.authorŞahin, M. Akif
dc.contributor.authorÇaylan, Ö. R.
dc.contributor.authorBüke, G. C.
dc.contributor.authorYıldırım, E.
dc.contributor.authorEroğlu, İ. C.
dc.contributor.authorErson-Bensan, A. E.
dc.contributor.authorÇetin, Barbaros
dc.contributor.authorÖzer, M. B.
dc.date.accessioned2023-02-15T11:56:56Z
dc.date.available2023-02-15T11:56:56Z
dc.date.issued2023-03
dc.departmentDepartment of Mechanical Engineeringen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractIn the present study, the capabilities of different chip materials for acoustic particle manipulation have been assessed with the same microfluidic device architecture, under the same actuator and flow conditions. Silicon, glass, epoxy with fiberglass filling (FR4), polydimethylsiloxane (PDMS) and polymethyl methacrylate (PMMA) are considered as chip materials. The acoustophoretic chips in this study were manufactured with four different fabrication methods: plasma etching, chemical etching, micromachining and molding. A novel chip material, FR4, has been employed as a microfluidic chip material in acoustophoretic particle manipulation for the first time in literature, which combines the ease of manufacturing of polymer materials with improved acoustic performance. The acoustic particle manipulation performance is evaluated through acoustophoretic focusing experiments with 2μm and 12μm polystyrene microspheres and cultured breast cancer cell line (MDA-MB-231). Unlike the common approach in the literature, the piezoelectric materials were actuated with partitioned cross-polarized electrodes which allowed effective actuation of different family of chip materials. Different from previous studies, this study evaluates the performance of each acoustophoretic device through the perspective of synchronization of electrical, vibrational and acoustical resonances, considers the thermal performance of the chip materials with their effects on cell viability as well as manufacturability and scalability of their fabrication methods. We believe our study is an essential work towards the commercialization of acoustophoretic devices since it brings a critical understanding of the effect of chip material on device performance as well as the cost of achieving that performance.en_US
dc.description.provenanceSubmitted by İrem Aro (iremaro18@gmail.com) on 2023-02-15T11:56:56Z No. of bitstreams: 1 Assessment_of_silicon,_glass,_FR4,_PDMS_and_PMMA_as_a_chip_material_for_acoustic_particlecell_manipulation_in_microfluidics.pdf: 3751619 bytes, checksum: 77f832294564a3792efcc98933e934f0 (MD5)en
dc.description.provenanceMade available in DSpace on 2023-02-15T11:56:56Z (GMT). No. of bitstreams: 1 Assessment_of_silicon,_glass,_FR4,_PDMS_and_PMMA_as_a_chip_material_for_acoustic_particlecell_manipulation_in_microfluidics.pdf: 3751619 bytes, checksum: 77f832294564a3792efcc98933e934f0 (MD5) Previous issue date: 2023-03en
dc.identifier.doi10.1016/j.ultras.2022.106911en_US
dc.identifier.urihttp://hdl.handle.net/11693/111349
dc.language.isoEnglishen_US
dc.relation.isversionofhttps://www.doi.org/10.1016/j.ultras.2022.106911en_US
dc.source.titleUltrasonicsen_US
dc.subjectAcoustofluidicsen_US
dc.subjectPiezoelectric actuatorsen_US
dc.subjectVibrationsen_US
dc.subjectUltrasonicsen_US
dc.subjectFR4en_US
dc.subjectCultured cancer cellsen_US
dc.titleAssessment of silicon, glass, FR4, PDMS and PMMA as a chip material for acoustic particle/cell manipulation in microfluidicsen_US
dc.typeArticleen_US

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Institute of Materials Science and Nanotechnology (UNAM)
Department of Mechanical Engineering