ZenoFishDb v1.1: a database for xenotransplantation studies in zebrafish

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buir.contributor.authorTargen, Seniye
buir.contributor.authorKaya, Tuğberk
buir.contributor.authorGüneş, Damla
buir.contributor.authorKeşküş, Ayşe Gökçe
buir.contributor.authorKonu, Özlen
dc.citation.epage318en_US
dc.citation.issueNumber5en_US
dc.citation.spage305en_US
dc.citation.volumeNumber17en_US
dc.contributor.authorTargen, Seniye
dc.contributor.authorKaya, Tuğberk
dc.contributor.authorAvcı, M. E.
dc.contributor.authorGüneş, Damla
dc.contributor.authorKeşküş, Ayşe Gökçe
dc.contributor.authorKonu, Özlen
dc.date.accessioned2021-03-04T06:51:04Z
dc.date.available2021-03-04T06:51:04Z
dc.date.issued2020
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentInterdisciplinary Program in Neuroscience (NEUROSCIENCE)en_US
dc.description.abstractRapidly accumulating literature has proven feasibility of the zebrafish xenograft models in cancer research. Nevertheless, online databases for searching the current zebrafish xenograft literature are in great demand. Herein, we have developed a manually curated database, called ZenoFishDb v1.1 (https://konulab.shinyapps.io/zenofishdb), based on R Shiny platform aiming to provide searchable information on ever increasing collection of zebrafish studies for cancer cell line transplantation and patient-derived xenografts (PDXs). ZenoFishDb v1.1 user interface contains four modules: DataTable, Visualization, PDX Details, and PDX Charts. The DataTable and Visualization pages represent xenograft study details, including injected cell lines, PDX injections, molecular modifications of cell lines, zebrafish strains, as well as technical aspects of the xenotransplantation procedures in table, bar, and/or pie chart formats. The PDX Details module provides comprehensive information on the patient details in table format and can be searched and visualized. Overall, ZenoFishDb v1.1 enables researchers to effectively search, list, and visualize different technical and biological attributes of zebrafish xenotransplantation studies particularly focusing on the new trends that make use of reporters, RNA interference, overexpression, or mutant gene constructs of transplanted cancer cells, stem cells, and PDXs, as well as distinguished host modifications.en_US
dc.identifier.doi10.1089/zeb.2020.1869en_US
dc.identifier.issn1545-8547
dc.identifier.urihttp://hdl.handle.net/11693/75755
dc.language.isoEnglishen_US
dc.publisherMary Ann Lieberten_US
dc.relation.isversionofhttps://dx.doi.org/10.1089/zeb.2020.1869en_US
dc.source.titleZebrafishen_US
dc.subjectZebrafishen_US
dc.subjectXenograften_US
dc.subjectCanceren_US
dc.subjectDatabaseen_US
dc.subjectR shinyen_US
dc.subjectPatient-derived xenograften_US
dc.titleZenoFishDb v1.1: a database for xenotransplantation studies in zebrafishen_US
dc.typeArticleen_US

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Department of Molecular Biology and Genetics
Aysel Sabuncu Brain Research Center (BAM)
Institute of Materials Science and Nanotechnology (UNAM)