Electrospinning of polymer-free cyclodextrin/geraniol-inclusion complex nanofibers: enhanced shelf-life of geraniol with antibacterial and antioxidant properties
buir.contributor.author | Uyar, Tamer | |
buir.contributor.orcid | Uyar, Tamer|0000-0002-3989-4481 | |
dc.citation.epage | 46099 | en_US |
dc.citation.issueNumber | 52 | en_US |
dc.citation.spage | 46089 | en_US |
dc.citation.volumeNumber | 6 | en_US |
dc.contributor.author | Aytac Z. | en_US |
dc.contributor.author | Yildiz, Z. I. | en_US |
dc.contributor.author | Kayaci-Senirmak, F. | en_US |
dc.contributor.author | Keskin, S. N. O. | en_US |
dc.contributor.author | Tekinay, T. | en_US |
dc.contributor.author | Uyar, Tamer | en_US |
dc.date.accessioned | 2018-04-12T10:48:10Z | |
dc.date.available | 2018-04-12T10:48:10Z | |
dc.date.issued | 2016 | en_US |
dc.department | Institute of Materials Science and Nanotechnology (UNAM) | en_US |
dc.department | Nanotechnology Research Center (NANOTAM) | en_US |
dc.description.abstract | Free-standing nanofibrous webs of cyclodextrin/geraniol-inclusion complex (CD/geraniol-IC-NF) showing antibacterial, antioxidant activity and slow release of geraniol were developed as flavour/fragrance releasing materials via electrospinning. The electrospinning of CD/geraniol-IC-NFs with uniform and bead-free morphology was achieved without using a polymer matrix. Three types of CDs modified with hydroxypropyl and methyl groups (HPβCD, MβCD, and HPγCD) were used to obtain CD/geraniol-IC-NFs. The polymer-free CD/geraniol-IC-NFs allow us to attain much higher geraniol loading (∼11%, w/w) when compared to electrospun polymeric nanofibers containing CD/geraniol-IC (∼5%, w/w). Geraniol has a volatile nature, yet, a significant amount of geraniol (∼60-90%) was preserved in CD/geraniol-IC-NFs due to the complexation, whereas evaporation of geraniol was unavoidable for polymeric nanofibers incorporating geraniol without cyclodextrin. Short-term (3 h) temperature dependent release (37 °C, 50 °C, and 75 °C) and long-term open air (50 days, at RT) release tests revealed that MβCD/geraniol-IC-NF released less geraniol compared to HPβCD/geraniol-IC-NF and HPγCD/geraniol-IC-NF, indicating that much stronger inclusion complexation was formed between MβCD and geraniol. The release of geraniol from CD/geraniol-IC-NFs prevented the colonization of Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria to a great extent, as observed in the antibacterial activity results. It was observed that CD/geraniol-IC-NFs had higher antioxidant activity compared to pure geraniol due to the solubility increase. In brief, the results reported here may open a new door to enhance the performance of essential oils and flavour/fragrances, to preserve volatile compounds from evaporation and to better understand the potential of CD/IC-NFs as carrier systems for guest compounds in the food, cosmetic and household cleaning industries. | en_US |
dc.description.provenance | Made available in DSpace on 2018-04-12T10:48:10Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2016 | en |
dc.identifier.doi | 10.1039/c6ra07088d | en_US |
dc.identifier.issn | 2046-2069 | |
dc.identifier.uri | http://hdl.handle.net/11693/36678 | |
dc.language.iso | English | en_US |
dc.publisher | Royal Society of Chemistry | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1039/c6ra07088d | en_US |
dc.source.title | RSC Advances | en_US |
dc.subject | Antioxidants | en_US |
dc.subject | Bacteria | en_US |
dc.subject | Cyclodextrins | en_US |
dc.subject | Electrospinning | en_US |
dc.subject | Escherichia coli | en_US |
dc.subject | Essential oils | en_US |
dc.subject | Evaporation | en_US |
dc.subject | Nanofibers | en_US |
dc.subject | Oils and fats | en_US |
dc.subject | Spinning (fibers) | en_US |
dc.subject | Thermal processing (foods) | en_US |
dc.subject | Volatile organic compounds | en_US |
dc.subject | Anti-bacterial activity | en_US |
dc.subject | Anti-oxidant activities | en_US |
dc.subject | Antioxidant properties | en_US |
dc.subject | Inclusion complexation | en_US |
dc.subject | Polymeric nanofibers | en_US |
dc.subject | Staphylococcus aureus | en_US |
dc.subject | Temperature dependent | en_US |
dc.subject | Volatile compounds | en_US |
dc.subject | Monoterpenes | en_US |
dc.title | Electrospinning of polymer-free cyclodextrin/geraniol-inclusion complex nanofibers: enhanced shelf-life of geraniol with antibacterial and antioxidant properties | en_US |
dc.type | Article | en_US |
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