Supramolecular GAG-like self-assembled glycopeptide nanofibers Induce chondrogenesis and cartilage regeneration

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buir.contributor.authorGüler, Mustafa O.
dc.citation.epage689en_US
dc.citation.issueNumber2en_US
dc.citation.spage679en_US
dc.citation.volumeNumber17en_US
dc.contributor.authorYaylaci, U. S.en_US
dc.contributor.authorEkiz, M. S.en_US
dc.contributor.authorArslan, E.en_US
dc.contributor.authorCan, N.en_US
dc.contributor.authorKilic, E.en_US
dc.contributor.authorOzkan, H.en_US
dc.contributor.authorOrujalipoor, I.en_US
dc.contributor.authorIde, S.en_US
dc.contributor.authorTekinay, A. B.en_US
dc.contributor.authorGüler, Mustafa O.en_US
dc.date.accessioned2018-04-12T10:51:56Z
dc.date.available2018-04-12T10:51:56Z
dc.date.issued2016en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractGlycosaminoglycans (GAGs) and glycoproteins are vital components of the extracellular matrix, directing cell proliferation, differentiation, and migration and tissue homeostasis. Here, we demonstrate supramolecular GAG-like glycopeptide nanofibers mimicking bioactive functions of natural hyaluronic acid molecules. Self-assembly of the glycopeptide amphiphile molecules enable organization of glucose residues in close proximity on a nanoscale structure forming a supramolecular GAG-like system. Our in vitro culture results indicated that the glycopeptide nanofibers are recognized through CD44 receptors, and promote chondrogenic differentiation of mesenchymal stem cells. We analyzed the bioactivity of GAG-like glycopeptide nanofibers in chondrogenic differentiation and injury models because hyaluronic acid is a major component of articular cartilage. Capacity of glycopeptide nanofibers on in vivo cartilage regeneration was demonstrated in microfracture treated osteochondral defect healing. The glycopeptide nanofibers act as a cell-instructive synthetic counterpart of hyaluronic acid, and they can be used in stem cell-based cartilage regeneration therapies.en_US
dc.identifier.doi10.1021/acs.biomac.5b01669en_US
dc.identifier.issn1525-7797
dc.identifier.urihttp://hdl.handle.net/11693/36747
dc.language.isoEnglishen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/acs.biomac.5b01669en_US
dc.source.titleBiomacromoleculesen_US
dc.subjectCell cultureen_US
dc.subjectCell proliferationen_US
dc.subjectCellsen_US
dc.subjectCytologyen_US
dc.subjectHyaluronic aciden_US
dc.subjectMoleculesen_US
dc.subjectNanofibersen_US
dc.subjectOrganic acidsen_US
dc.subjectPeptidesen_US
dc.subjectSelf assemblyen_US
dc.subjectStem cellsen_US
dc.subjectSupramolecular chemistryen_US
dc.subjectTissueen_US
dc.subjectTissue homeostasisen_US
dc.subjectAmphiphile moleculesen_US
dc.subjectArticular cartilagesen_US
dc.subjectCartilage regenerationen_US
dc.subjectChondrogenic differentiationen_US
dc.subjectExtracellular matricesen_US
dc.subjectMesenchymal stem cellen_US
dc.subjectNanoscale structureen_US
dc.subjectOsteochondral defectsen_US
dc.subjectCartilageen_US
dc.subjectHermes antigenen_US
dc.subjectCd44 protein, mouseen_US
dc.subjectHermes antigenen_US
dc.subjectCartilageen_US
dc.subjectMesenchymal Stromal Cellsen_US
dc.subjectMolecular Mimicryen_US
dc.subjectRegenerationen_US
dc.subjectScattering, Small Angleen_US
dc.subjectTissue Scaffoldsen_US
dc.subjectX-Ray Diffractionen_US
dc.titleSupramolecular GAG-like self-assembled glycopeptide nanofibers Induce chondrogenesis and cartilage regenerationen_US
dc.typeArticleen_US

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Institute of Materials Science and Nanotechnology (UNAM)
Nanotechnology Research Center (NANOTAM)