Browsing by Subject "Near-IR"

Filter results by typing the first few letters
Now showing 1 - 2 of 2
  • Thumbnail Image
    ItemOpen Access
    Near-IR absorbing BODIPY derivatives as glutathione-activated photosensitizers for selective photodynamic action
    (Wiley-VCH Verlag, 2014) Turan, I. S.; Cakmak, F. P.; Yildirim, D. C.; Cetin Atalay, R.; Akkaya, E. U.
    Enhanced spatiotemporal selectivity in photonic sensitization of dissolved molecular oxygen is an important target for improving the potential and the practical applications of photodynamic therapy. Considering the high intracellular glutathione concentrations within cancer cells, a series of BODIPY-based sensitizers that can generate cytotoxic singlet oxygen only after glutathione-mediated cleavage of the electron-sink module were designed and synthesized. Cell culture studies not only validate our design, but also suggest an additional role for the relatively hydrophobic quencher module in the internalization of the photosensitizer.
  • Thumbnail Image
    ItemOpen Access
    Near-IR-triggered, remote-controlled release of metal ions: A novel strategy for caged ions
    (Wiley-VCH Verlag, 2014) Atilgan, A.; Eçik, E. T.; Guliyev, R.; Uyar, T. B.; Erbas-Cakmak, S.; Akkaya, E. U.
    A ligand incorporating a dithioethenyl moiety is cleaved into fragments which have a lower metal-ion affinity upon irradiation with low-energy red/near-IR light. The cleavage is a result of singlet oxygen generation which occurs on excitation of the photosensitizer modules. The method has many tunable factors that could make it a satisfactory caging strategy for metal ions.