Browsing by Subject "Modified cyclodextrins"

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Open Access
Electrospinning of cyclodextrin/linalool-inclusion complex nanofibers: fast-dissolving nanofibrous web with prolonged release and antibacterial activity
(Elsevier, 2017-09) Aytac Z.; Yildiz, Z. I.; Kayaci-Senirmak, F.; Tekinay, T.; Uyar, Tamer
The volatility and limited water solubility of linalool is a critical issue to be solved. Here, we demonstrated the electrospinning of polymer-free nanofibrous webs of cyclodextrin/linalool-inclusion complex (CD/linalool-IC-NFs). Three types of modified cyclodextrin (HPβCD, MβCD, and HPγCD) were used to electrospin CD/linalool-IC-NFs. Free-standing CD/linalool-IC-NFs facilitate maximum loading of linalool up to 12% (w/w). A significant amount of linalool (45–89%) was preserved in CD/linalool-IC-NFs, due to enhancement in the thermal stability of linalool by cyclodextrin inclusion complexation. Remarkably, CD/linalool-IC-NFs have shown fast-dissolving characteristics in which these nanofibrous webs dissolved in water within two seconds. Furthermore, linalool release from CD/linalool-IC-NFs inhibited growth of model Gram-negative (E. coli) and Gram-positive (S. aureus) bacteria to a great extent. Briefly, characteristics of liquid linalool have been preserved in a solid nanofiber form and designed CD/linalool-IC-NFs confer high loading capacity, enhanced shelf life and strong antibacterial activity of linalool.
Open Access
Encapsulation of food additives and drugs by cyclodextrin functionalized electrospun nanofibers
(2020-06) Yıldız, Zehra İrem
Electrospun nanofibers attract attention of many areas including food and pharmaceutical industries thanks to their unique physical/mechanical properties like large surface area-to-volume ratio, nanoporous structure, design flexibility and lightweight. Although, in general polymers are used for fabrication of electrospun nanofibers, it is also possible to obtain electrospun nanofibers purely from cyclodextrins (CDs). CDs with truncated cone shape structure are attractive host molecules for the formation of host-guest type inclusion complexes (ICs) with variety of appropriate guest molecules. Creating ICs with CDs causes remarkable enhancement at the properties of the guest molecule, and so CDs have wide range of applications in many areas including food and pharmaceutical industries. In this thesis, polymer-free electrospun nanofibers from CD-ICs of some food additives and drugs were produced. Firstly, four food additives, menthol, carvacrol, cinnamaldehyde and beta-carotene were encapsulated by electrospun CD nanofibers. Afterwards, the solubility, heat/light stability, antibacterial/antioxidant activity of the materials were investigated to observe the effects of encapsulation by CD nanofibers on the food additives. Secondly, electrospun CD-IC nanofibers of three types of drugs, sulfisoxazole, paracetamol and catechin were produced. Since one of the most critical point for drug bioavailability is its solubility in water, the obtained electrospun drug/CD-IC nanofibers were mainly investigated in terms of change in their solubility. In the light of analyses, it can be concluded that, main drawbacks of food additives and drugs like high volatility, low solubility and low stability were reduced or removed; besides, their properties such as antioxidant and antibacterial activities were enhanced or preserved.
Open Access
Fast-dissolving, prolonged release, and antibacterial cyclodextrin/limonene-inclusion complex nanofibrous webs via polymer-free electrospinning
(American Chemical Society, 2016) Aytac Z.; Yildiz, Z. I.; Kayaci-Senirmak, F.; S. Keskin, N. O.; Kusku, S. I.; Durgun, Engin; Tekinay, T.; Uyar, Tamer
We have proposed a new strategy for preparing free-standing nanofibrous webs from an inclusion complex (IC) of a well-known flavor/fragrance compound (limonene) with three modified cyclodextrins (HPβCD, MβCD, and HPγCD) via electrospinning (CD/limonene-IC-NFs) without using a polymeric matrix. The experimental and computational modeling studies proved that the stoichiometry of the complexes was 1:1 for CD/limonene systems. MβCD/limonene-IC-NF released much more limonene at 37, 50, and 75 °C than HPβCD/limonene-IC-NF and HPγCD/limonene-IC-NF because of the greater amount of preserved limonene. Moreover, MβCD/limonene-IC-NF has released only 25% (w/w) of its limonene, whereas HPβCD/limonene-IC-NF and HPγCD/limonene-IC-NF released 51 and 88% (w/w) of their limonene in 100 days, respectively. CD/limonene-IC-NFs exhibited high antibacterial activity against E. coli and S. aureus. The water solubility of limonene increased significantly and CD/limonene-IC-NFs were dissolved in water in a few seconds. In brief, CD/limonene-IC-NFs with fast-dissolving character enhanced the thermal stability and prolonged the shelf life along with antibacterial properties could be quite applicable in food and oral care applications.