Electrospinning of cyclodextrin/linalool-inclusion complex nanofibers: fast-dissolving nanofibrous web with prolonged release and antibacterial activity

Date
2017-09
Advisor
Instructor
Source Title
Food Chemistry
Print ISSN
0308-8146
Electronic ISSN
Publisher
Elsevier
Volume
231
Issue
Pages
192 - 201
Language
English
Type
Article
Journal Title
Journal ISSN
Volume Title
Abstract

The volatility and limited water solubility of linalool is a critical issue to be solved. Here, we demonstrated the electrospinning of polymer-free nanofibrous webs of cyclodextrin/linalool-inclusion complex (CD/linalool-IC-NFs). Three types of modified cyclodextrin (HPβCD, MβCD, and HPγCD) were used to electrospin CD/linalool-IC-NFs. Free-standing CD/linalool-IC-NFs facilitate maximum loading of linalool up to 12% (w/w). A significant amount of linalool (45–89%) was preserved in CD/linalool-IC-NFs, due to enhancement in the thermal stability of linalool by cyclodextrin inclusion complexation. Remarkably, CD/linalool-IC-NFs have shown fast-dissolving characteristics in which these nanofibrous webs dissolved in water within two seconds. Furthermore, linalool release from CD/linalool-IC-NFs inhibited growth of model Gram-negative (E. coli) and Gram-positive (S. aureus) bacteria to a great extent. Briefly, characteristics of liquid linalool have been preserved in a solid nanofiber form and designed CD/linalool-IC-NFs confer high loading capacity, enhanced shelf life and strong antibacterial activity of linalool.

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Book Title
Keywords
Antibacterial activity, Cyclodextrin, Electrospinning, Inclusion complex, Linalool, Nanofiber, Nanofibers, Release, Alcohols, Cyclodextrins, Dissolution, Electrospinning, Spinning (fibers), Thermodynamic stability, Anti-bacterial activity, Inclusion complex, Inclusion complexation, Linalool, Modified cyclodextrins, Prolonged release, Release, Water solubilities, Nanofibers
Citation
Published Version (Please cite this version)