Browsing by Subject "Drug"

Now showing 1 - 4 of 4

Open Access
Conjugated polymer nanoparticles
(2010) Tuncel, D.; Demir, Hilmi Volkan
Conjugated polymer nanoparticles are highly versatile nano-structured materials that can potentially find applications in various areas such as optoelectronics, photonics, bio-imaging, bio-sensing and nanomedicine. Their straightforward synthesis in desired sizes and properties, biocompatibility and non-toxicity make these materials highly attractive for the aforementioned applications. This feature article reviews the recent developments in the synthesis, characterization, properties and application of these exciting nanostructured materials.
Open Access
Drug delivery system based on cyclodextrin-naproxen inclusion complex incorporated in electrospun polycaprolactone nanofibers
(Elsevier, 2014) Canbolat, M. F.; Celebioglu A.; Uyar, Tamer
In this study, we select naproxen (NAP) as a reference drug and electrospun poly (e-caprolactone) (PCL) nanofibers as a fibrous matrix for our drug-delivery system. NAP was complexed with beta-cyclodextrin (βCD) to form inclusion complex (NAP-βCD-IC) and then NAP-βCD-IC was incorporated into PCL nanofibers via electrospinning. The incorporation of NAP without CD-IC into electrospun PCL was also carried out for a comparative study. Our aim is to analyze the release profiles of NAP from PCL/NAP and PCL/NAP-βCD-IC nanofibers and we investigate the effect of CD-IC on the release behavior of NAP from the nanofibrous PCL matrix. The characterization of NAP-βCD-IC and the presence of CD-IC in PCL/NAP-βCD-IC nanofibers were studied by FTIR, XRD, TGA, NMR and SEM. The SEM imaging of the electrospun PCL/NAP and PCL/NAP-βCD-IC nanofibers reveal that the average fiber diameter of these nanofibers is around 300. nm, in addition, the aggregates of CD-IC in PCL/NAP-βCD-IC nanofibers is observed. The release study of NAP in buffer solution elucidate that the PCL/NAP-βCD-IC nanofibers have higher release amount of NAP than the PCL/NAP nanofibers due to the solubility enhancement of NAP by CD-IC.
Open Access
Drug repurposing and investigation of novel combinations for glioblastoma therapeutics using in vitro and zebrafish in vivo models
(2024-01) Tok, Güneş
Glioblastoma is the most common and aggressive brain cancer type with the survival rate less than 2 years after diagnosis. Yet, potent drug treatments used in patients are limited and the field is in need of development of new potential drugs. In this study, repurposing of approved drugs alone or in combination and novel drugs are investigated in terms of inhibition of cell viability, glial fluorescent signals and their effects on behavior in zebrafish larval models. The main aim of this study was to test whether phenothiazines, trifluoperazine and a novel molecule 10, could be repurposed for glioblastoma treatment with lower dosages and more potency when combined with Sorafenib, an approved drug, in glioblastoma cell lines and zebrafish larvae. Those drug combinations were not found as toxic in the dosages studied while acted on glia cells in zebrafish transgenic larval models. Last but not least, behavior and stress response of the wild type and heterozygous mutant ache larvae in comparison with homozygous siblings were tested upon drug administration to assess genotype by drug interactions. Combination treatments exhibited higher efficacies suggesting phenothiazines with sorafenib could have potential in glioblastoma treatment. Genotype specific effects of individual and combination treatments on larval light-dark behavior, stress response and recovery exhibited potential for passage of blood brain barrier by the tested drugs. The established protocols for genotype and drug interactions could be applied to other kinases in combination with phenothiazines.
Open Access
Tüketiciler ve genetiği değiştirilmiş ürün grupları: algılar ve etik inançlar üzerine bir araştırma
(Akdeniz Üniversitesi İletişim Fakültesi, 2013) Özgen, Ö.; Emiroğlu, Haluk; Serpen, A. S.; Benlioğlu, B.
Bu araştırma, tüketicilerin genetiği değiştirilmiş ürün gruplarına yönelik (gıda, ilaç, kozmetik ve deterjan) fayda-risk algıları ile etik inançlarının belirlenmesi amacı ile planlanmış ve yürütülmüştür. Ankara’da kamu sektöründe çalışan tüketiciler tesadüfi örnekleme yöntemi kullanılarak araştırmaya dahil edilmiştir. Araştırma materyalinin toplanmasında karşılıklı görüşme tekniği kullanılmış, cinsiyet ve yaş değişkenlerine bağlı farklılığın belirlenebilmesi için t-testi uygulanmıştır. Bulgular, gıda, kozmetik ve deterjanlar söz konusu olduğunda yaş değişkeninin ilaçlar söz konusu olduğunda ise hem yaş hem de cinsiyet değişkeninin etkili olduğunu göstermektedir.