Drug delivery system based on cyclodextrin-naproxen inclusion complex incorporated in electrospun polycaprolactone nanofibers

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Drug delivery system based on cyclodextrin-naproxen inclusion complex incorporated in electrospun polycaprolactone nanofibers.pdf (1.58 MB)

Date

2014

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Source Title

Colloids and Surfaces B: Biointerfaces

Print ISSN

0927-7765

Electronic ISSN

Publisher

Elsevier

Volume

115

Issue

Pages

15 - 21

Language

English

Type

Article

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Abstract

In this study, we select naproxen (NAP) as a reference drug and electrospun poly (e-caprolactone) (PCL) nanofibers as a fibrous matrix for our drug-delivery system. NAP was complexed with beta-cyclodextrin (βCD) to form inclusion complex (NAP-βCD-IC) and then NAP-βCD-IC was incorporated into PCL nanofibers via electrospinning. The incorporation of NAP without CD-IC into electrospun PCL was also carried out for a comparative study. Our aim is to analyze the release profiles of NAP from PCL/NAP and PCL/NAP-βCD-IC nanofibers and we investigate the effect of CD-IC on the release behavior of NAP from the nanofibrous PCL matrix. The characterization of NAP-βCD-IC and the presence of CD-IC in PCL/NAP-βCD-IC nanofibers were studied by FTIR, XRD, TGA, NMR and SEM. The SEM imaging of the electrospun PCL/NAP and PCL/NAP-βCD-IC nanofibers reveal that the average fiber diameter of these nanofibers is around 300. nm, in addition, the aggregates of CD-IC in PCL/NAP-βCD-IC nanofibers is observed. The release study of NAP in buffer solution elucidate that the PCL/NAP-βCD-IC nanofibers have higher release amount of NAP than the PCL/NAP nanofibers due to the solubility enhancement of NAP by CD-IC.

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Keywords

Cyclodextrin , Drug , Inclusion complex , Nanofibers , Naproxen , Release , Cyclodextrins , Drug delivery , Polycaprolactone , Average fiber diameters , Drug , Drug-delivery systems , Inclusion complex , Naproxens , Poly(ecaprolactone) (PCL) , Release , Solubility enhancement , Nanofibers , Beta cyclodextrin , Buffer , Nanofiber , Naproxen , Polycaprolactone , Polycaprolactone nanofiber , Unclassified drug , Beta cyclodextrin , Beta cyclodextrin derivative , Nanofiber , Naproxen , Polycaprolactone , Polyester , Article , Complex formation , Controlled study , Drug delivery system , Drug release , Drug solubility , Electrospinning , Infrared spectroscopy , Particle size , Physical chemistry , Priority journal , Proton nuclear magnetic resonance , Scanning electron microscopy , Thermogravimetry , X ray diffraction , Chemistry , High performance liquid chromatography , Nuclear magnetic resonance spectroscopy , Procedures , Solubility , Tissue engineering , Ultrastructure , Ultraviolet spectrophotometry , Beta-Cyclodextrins , Chromatography, High Pressure Liquid , Drug Delivery Systems , Magnetic Resonance Spectroscopy , Nanofibers , Naproxen , Polyesters , Solubility , Spectrophotometry, Ultraviolet , Spectroscopy, Fourier Transform Infrared , Thermogravimetry , Tissue Engineering , X-Ray Diffraction

Citation

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http://hdl.handle.net/11693/26315

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http://dx.doi.org/10.1016/j.colsurfb.2013.11.021

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Institute of Materials Science and Nanotechnology (UNAM)
Nanotechnology Research Center (NANOTAM)