Drug delivery system based on cyclodextrin-naproxen inclusion complex incorporated in electrospun polycaprolactone nanofibers

Date
2014
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Source Title
Colloids and Surfaces B: Biointerfaces
Print ISSN
0927-7765
Electronic ISSN
Publisher
Elsevier
Volume
115
Issue
Pages
15 - 21
Language
English
Type
Article
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Abstract

In this study, we select naproxen (NAP) as a reference drug and electrospun poly (e-caprolactone) (PCL) nanofibers as a fibrous matrix for our drug-delivery system. NAP was complexed with beta-cyclodextrin (βCD) to form inclusion complex (NAP-βCD-IC) and then NAP-βCD-IC was incorporated into PCL nanofibers via electrospinning. The incorporation of NAP without CD-IC into electrospun PCL was also carried out for a comparative study. Our aim is to analyze the release profiles of NAP from PCL/NAP and PCL/NAP-βCD-IC nanofibers and we investigate the effect of CD-IC on the release behavior of NAP from the nanofibrous PCL matrix. The characterization of NAP-βCD-IC and the presence of CD-IC in PCL/NAP-βCD-IC nanofibers were studied by FTIR, XRD, TGA, NMR and SEM. The SEM imaging of the electrospun PCL/NAP and PCL/NAP-βCD-IC nanofibers reveal that the average fiber diameter of these nanofibers is around 300. nm, in addition, the aggregates of CD-IC in PCL/NAP-βCD-IC nanofibers is observed. The release study of NAP in buffer solution elucidate that the PCL/NAP-βCD-IC nanofibers have higher release amount of NAP than the PCL/NAP nanofibers due to the solubility enhancement of NAP by CD-IC.

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Keywords
Cyclodextrin, Drug, Inclusion complex, Nanofibers, Naproxen, Release, Cyclodextrins, Drug delivery, Polycaprolactone, Average fiber diameters, Drug, Drug-delivery systems, Inclusion complex, Naproxens, Poly(ecaprolactone) (PCL), Release, Solubility enhancement, Nanofibers, Beta cyclodextrin, Buffer, Nanofiber, Naproxen, Polycaprolactone, Polycaprolactone nanofiber, Unclassified drug, Beta cyclodextrin, Beta cyclodextrin derivative, Nanofiber, Naproxen, Polycaprolactone, Polyester, Article, Complex formation, Controlled study, Drug delivery system, Drug release, Drug solubility, Electrospinning, Infrared spectroscopy, Particle size, Physical chemistry, Priority journal, Proton nuclear magnetic resonance, Scanning electron microscopy, Thermogravimetry, X ray diffraction, Chemistry, High performance liquid chromatography, Nuclear magnetic resonance spectroscopy, Procedures, Solubility, Tissue engineering, Ultrastructure, Ultraviolet spectrophotometry, Beta-Cyclodextrins, Chromatography, High Pressure Liquid, Drug Delivery Systems, Magnetic Resonance Spectroscopy, Nanofibers, Naproxen, Polyesters, Solubility, Spectrophotometry, Ultraviolet, Spectroscopy, Fourier Transform Infrared, Thermogravimetry, Tissue Engineering, X-Ray Diffraction
Citation
Published Version (Please cite this version)