Browsing by Author "Uyar, T. B."

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    Modular logic gates: cascading independent logic gates via metal ion signals
    (Royal Society of Chemistry, 2014) Ecik, E. T.; Atilgan, A.; Guliyev, R.; Uyar, T. B.; Gumus, A.; Akkaya, E. U.
    Systematic cascading of molecular logic gates is an important issue to be addressed for advancing research in this field. We have demonstrated that photochemically triggered metal ion signals can be utilized towards that goal. Thus, independent logic gates were shown to work together while keeping their identity in more complex logic designs. Communication through the intermediacy of ion signals is clearly inspired from biological processes modulated by such signals, and implemented here with ion responsive molecules.
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    Near-IR-triggered, remote-controlled release of metal ions: A novel strategy for caged ions
    (Wiley-VCH Verlag, 2014) Atilgan, A.; Eçik, E. T.; Guliyev, R.; Uyar, T. B.; Erbas-Cakmak, S.; Akkaya, E. U.
    A ligand incorporating a dithioethenyl moiety is cleaved into fragments which have a lower metal-ion affinity upon irradiation with low-energy red/near-IR light. The cleavage is a result of singlet oxygen generation which occurs on excitation of the photosensitizer modules. The method has many tunable factors that could make it a satisfactory caging strategy for metal ions.
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    Selective photosensitization through an and logic response: optimization of the pH and glutathione response of activatable photosensitizers
    (Royal Society of Chemistry, 2015) Erbas-Cakmak, S.; Cakmak, F. P.; Topel, S. D.; Uyar, T. B.; Akkaya, E. U.
    A series of pH and GSH responsive photosensitizers were designed and synthesized. pKa values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0-7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quencher from the PS by GSH allow the construction of an AND logic operator for selective photodynamic action in aqueous solutions.
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    Singlet oxygen generation with chemical excitation of an erythrosine-luminol conjugate
    (American Chemical Society, 2017) Yesilgul, N.; Uyar, T. B.; Seven, O.; Akkaya, E. U.
    Chemical generation of singlet oxygen under biologically relevant conditions is very important, considering the role played by singlet oxygen in cancer therapeutics. We now demonstrate that a luminol derivative can be chemically excited and transfer the excitation energy to the covalently attached photosensitizer derived from erythrosin. A photosensitizer module, when excited in this manner, can generate singlet oxygen in solution. As hydrogen peroxide is present in a relatively high concentration in cancer cells, singlet oxygen generation through chemical excitation may evolve into an important therapeutic approach.