Selective photosensitization through an and logic response: optimization of the pH and glutathione response of activatable photosensitizers
Date
2015
Authors
Erbas-Cakmak, S.
Cakmak, F. P.
Topel, S. D.
Uyar, T. B.
Akkaya, E. U.
Editor(s)
Advisor
Supervisor
Co-Advisor
Co-Supervisor
Instructor
Source Title
Chemical Communications
Print ISSN
1359-7345
Electronic ISSN
1364-548X
Publisher
Royal Society of Chemistry
Volume
51
Issue
61
Pages
12258 - 12261
Language
English
Type
Journal Title
Journal ISSN
Volume Title
Series
Abstract
A series of pH and GSH responsive photosensitizers were designed and synthesized. pKa values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0-7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quencher from the PS by GSH allow the construction of an AND logic operator for selective photodynamic action in aqueous solutions.