Selective photosensitization through an and logic response: optimization of the pH and glutathione response of activatable photosensitizers

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Selective photosensitization through an AND logic response optimization of the pH and glutathione response of activatable photosensitizers.pdf (1.88 MB)

Date

2015

Authors

Erbas-Cakmak, S.
Cakmak, F. P.
Topel, S. D.
Uyar, T. B.
Akkaya, E. U.

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Abstract

A series of pH and GSH responsive photosensitizers were designed and synthesized. pKa values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0-7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quencher from the PS by GSH allow the construction of an AND logic operator for selective photodynamic action in aqueous solutions.

Source Title

Chemical Communications

Publisher

Royal Society of Chemistry

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pKa

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http://hdl.handle.net/11693/21347

Published Version (Please cite this version)

http://dx.doi.org/10.1039/c5cc01261a

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Scholarly Publications - Chemistry

Language

English

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Article