Browsing by Author "Ichinose, A."
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Item Open Access An agar-coated cellophane method for bacterial observation using scanning and transmission electron microscopy(2002) Ichinose, A.; Ahmed, K.; Watanabe, K.; Izumi, S.; Hirayama, T.; Nagatake, T.Item Open Access Role of lipooligosaccharide in the attachment of Moraxella catarrhalis to human pharyngeal epithelial cells(Wiley, 2005) Akgul, G.; Erturk, A.; Turkoz, M.; Turan, T.; Ichinose, A.; Nagatake, T.; Ahmed, K.The goal of this study was to determine the role of lipooligosaccharide in the attachment of Moraxella catarrhalis to human pharyngeal epithelial cells. Strain 2951 and its Pk mutant strain 2951 galE were used in this study. This study suggests that the Pk epitope of LOS is not an adhesin for M. catarrhalis, but plays a crucial role by its surface charge in the initial stage of attachment.Item Open Access Variation in the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells after treatment with S-carboxymethylcysteine(2008) Suer, E.; Sayrac, S.; Sarinay, E.; Ozturk H.E.; Turkoz, M.; Ichinose, A.; Nagatake, T.; Ahmed, K.S-carboxymethylcysteine (S-CMC) is a mucolytic agent that can prevent respiratory infection by decreasing the attachment of respiratory pathogens to human pharyngeal epithelial cells (HPECs). Streptococcus pneumoniae is a major cause of respiratory infections. A previous study revealed that treatment of S. pneumoniae with S-CMC caused a decrease in the attachment of this bacterium to HPECs. In the present study we found that the effect of S-CMC varied according to hosts and strains. S-CMC treatment altered the surface structure of S. pneumoniae, resulting in a decrease of attachment, without affecting the virulence of the bacteria. © 2008 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.