Variation in the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells after treatment with S-carboxymethylcysteine

Date
2008
Authors
Suer, E.
Sayrac, S.
Sarinay, E.
Ozturk H.E.
Turkoz, M.
Ichinose, A.
Nagatake, T.
Ahmed, K.
Advisor
Instructor
Source Title
Journal of Infection and Chemotherapy
Print ISSN
1341321X
Electronic ISSN
Publisher
Volume
14
Issue
4
Pages
333 - 336
Language
English
Type
Article
Journal Title
Journal ISSN
Volume Title
Abstract

S-carboxymethylcysteine (S-CMC) is a mucolytic agent that can prevent respiratory infection by decreasing the attachment of respiratory pathogens to human pharyngeal epithelial cells (HPECs). Streptococcus pneumoniae is a major cause of respiratory infections. A previous study revealed that treatment of S. pneumoniae with S-CMC caused a decrease in the attachment of this bacterium to HPECs. In the present study we found that the effect of S-CMC varied according to hosts and strains. S-CMC treatment altered the surface structure of S. pneumoniae, resulting in a decrease of attachment, without affecting the virulence of the bacteria. © 2008 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.

Course
Other identifiers
Book Title
Keywords
Epithelial cells, Human, S-carboxymethylcysteine, Streptococcus pneumoniae, carbocisteine, penicillin G, adult, animal experiment, animal model, antibiotic resistance, article, bacterial virulence, bacterium adherence, controlled study, drug effect, electron microscopy, epithelium cell, female, human, human cell, male, minimum inhibitory concentration, mortality, mouse, nonhuman, normal human, penicillin resistance, pharynx, respiratory tract infection, Streptococcus pneumoniae, Animals, Bacterial Adhesion, Carbocysteine, Epithelial Cells, Expectorants, Female, Humans, Mice, Pharynx, Respiratory Tract Infections, Streptococcus pneumoniae
Citation
Published Version (Please cite this version)