Browsing by Author "Bilgin, S."
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Item Open Access Comparison of different balance scales in Parkinson's disease(Turkey Association of Physiotherapists, 2009) Gündüz, A. G.; Otman, A. S.; Kose, N.; Bilgin, S.; Elibol, B.Purpose: The main purpose of our study is finding out whether different methods used in evaluating balance are reliable and valid for Parkinson Disease. Material and methods: In the study, thirty idiopathic Parkinson patients were evaluated by Berg Balance Scale, Tinetti Performance Oriented Balance and Gait Scale, and clinical balance and mobility tests at their "off" and "on" periods. Additionally; the patients were evaluated by motor evaluation part of Unified Parkinson's Disease Rating Scale, Modified Hoehn and Yahr Scale. All the evaluation tests were repeated 7 days after the first applications. Results: Comparisons revealed that all the balance evaluation tests were reliable and valid for Parkinson patients. On the other hand, it was also revealed that, Berg Balance Scale is more reliable (ICC=0.99) and showing higher correlation with motor part of Unified Parkinson's Disease Rating Scale (r=-0.75, p<0.05) and Modified Hoehn and Yahr Scale (r=-0.75/0.71, p<0.05). Conclusion: As a result of our study, that Berg Balance Scale, Tinetti Performance Oriented Balance and Gait Scale, clinical balance and mobility tests can be applied to Parkinson disease patients reliably, and among these tests Berg Balance Scale gives more comprehensive information regarding evaluation of different parameters of balance.Item Open Access Xenogenic neural stem cell-derived extracellular nanovesicles modulate human mesenchymal stem cell fate and reconstruct metabolomic structure(Wiley-VCH Verlag GmbH & Co. KGaA, 2022-03-28) Derkus, B.; Isik, M.; Eylem, C. C.; Ergin, İ.; Camci, C. B.; Bilgin, S.; Elbüken, Çaglar; Arslan, Y. E.; Akkulak, M.; Adali, O.; Kiran, F.; Okesola, B. O.; Nemutlu, E.; Emregul, E.Extracellular nanovesicles, particularly exosomes, can deliver their diverse bioactive biomolecular content, including miRNAs, proteins, and lipids, thus providing a context for investigating the capability of exosomes to induce stem cells toward lineage-specific cells and tissue regeneration. In this study, it is demonstrated that rat subventricular zone neural stem cell-derived exosomes (rSVZ-NSCExo) can control neural-lineage specification of human mesenchymal stem cells (hMSCs). Microarray analysis shows that the miRNA content of rSVZ-NSCExo is a faithful representation of rSVZ tissue. Through immunocytochemistry, gene expression, and multi-omics analyses, the capability to use rSVZ-NSCExo to induce hMSCs into a neuroglial or neural stem cell phenotype and genotype in a temporal and dose-dependent manner via multiple signaling pathways is demonstrated. The current study presents a new and innovative strategy to modulate hMSCs fate by harnessing the molecular content of exosomes, thus suggesting future opportunities for rSVZ-NSCExo in nerve tissue regeneration.