Genetics and Biotechnology Research Center (BİLGEN)

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Browsing Genetics and Biotechnology Research Center (BİLGEN) by Author "Aslam, A."

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    Comparative evaluation of in vitro cytotoxic effects among parent abietyl alcohol and novel fatty acid ester derivatives against MCF7 and hepatocellular carcinoma cell lines
    (Pakistan Journal of Pharmaceutical Sciences, 2014) Mustufa, Muhammad Ayaz; Aslam, A.; Özen, Çiğdem; Hashmi, I. A.; Naqvi, N.; Öztürk, Mehmet; Ali, F. I.
    Synthesis of twelve hitherto unreported esters of abietyl alcohol and screening of these esters against four cancer cell lines including one breast cancer line MCF7 and four hepatocellular carcinoma cell lines (HCC) Huh7, Hep3B, Snu449 and Plc has been determined using SRB assay. The Cell cycle progression showed changes in cellular behaviour after 48 and 72 hours in MCF7 and Huh7 cell lines. Abietyl alcohol was obtained from the reduction of abietic acid, a tricyclic diterpene, isolated from oleoresin of Pinus longifolia Roxberghii.
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    Synthesis and characterization of amino acid conjugates of oleanolic acid and their in vitro cytotoxic effect on HCC cell lines
    (Pakistan Journal of Pharmaceutical Sciences, 2014) Mustufa, Muhammad Ayaz; Hashmi, I. A.; Manzoor, S.; Ahmed, A.; Ahmed, V.; Aslam, A.; Özen, Çiğdem; Naqvi, N.; Öztürk, Mehmet; Ali, F. I.
    Oleanolic acid (3β-hydroxy-olean-12-en-28-oic acid; OA-01), a pentacyclic triterpene, exhibit a wide range of pharmacological and biological activities. We have isolated oleanolic acid from methanolic extract of Periploca aphylla, collected from surroundings of Karachi in the month of February. Furthermore, four known and two new C-28 amino acid conjugates of oleanolic acid were prepared to explore potential of these compounds on HCCs and one breast cancer cell line. Cytotoxic effects revealed that as compare to parent compound (OA-01), two derivatives OA-04 (p<0.0001) and OA-06 (p<0.01) showed significantly increased/higher inhibition rates.