Comparative evaluation of in vitro cytotoxic effects among parent abietyl alcohol and novel fatty acid ester derivatives against MCF7 and hepatocellular carcinoma cell lines

Date
2014
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Source Title
Pakistan Journal of Pharmaceutical Sciences
Print ISSN
1011-601X
Electronic ISSN
Publisher
Pakistan Journal of Pharmaceutical Sciences
Volume
27
Issue
6
Pages
2013 - 2018
Language
English
Type
Article
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Abstract

Synthesis of twelve hitherto unreported esters of abietyl alcohol and screening of these esters against four cancer cell lines including one breast cancer line MCF7 and four hepatocellular carcinoma cell lines (HCC) Huh7, Hep3B, Snu449 and Plc has been determined using SRB assay. The Cell cycle progression showed changes in cellular behaviour after 48 and 72 hours in MCF7 and Huh7 cell lines. Abietyl alcohol was obtained from the reduction of abietic acid, a tricyclic diterpene, isolated from oleoresin of Pinus longifolia Roxberghii.

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Keywords
Abietic acid, Cancer cell lines, Diterpene, SRB assay, Steglich esterification
Citation
Published Version (Please cite this version)